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- W3032515983 abstract "ObjectiveTo analyze the effect of viable bifidobacterium quadruple tablets in the treatment of diarrhea induced irritable bowel syndrome and its effect on serum 5- serotonin and substance P.Methods90 cases of diarrhea type irritable bowel syndrome were randomly divided into two groups. 45 cases in the conventional group were treated with trimebutine maleate combined with Bacillus licheniformis, on the basis of the conventional group therapy, 45 cases in the study group were treated with viable bifidobacterium quadruple tablets. The two groups were treated for 8 weeks. The clinical efficacy, digestive tract symptoms, serum 5- serotonin and substance P levels were compared between the two groups.ResultsAfter 8 weeks of treatment, the total effective rate of the study group was 93.33%, which was higher than that of the conventional group (77.78%), with statistically significant difference (P<0.05); the scores of symptom frequency and symptom degree of the study group were lower than those of the conventional group, with statistically significant differences (P<0.05); the recovery time of the characters and times of stool of the study group were shorter than those of the conventional group, with statistically significant differences (P<0.05); the levels of serum 5- serotonin and substance P of the study group were lower than those of the conventional group, with statistically significant differences (P<0.05).ConclusionOn the basis of routine gastrointestinal motility drug therapy plus viable bifidobacterium quadruple adjuvant therapy can improve the therapeutic effect of diarrhea induced irritable bowel syndrome, which may be related to the reduction of 5- serotonin and substance P release.Key words: Diarrhea induced irritable bowel syndrome; Viable bifidobacterium quadruple tablets; 5-serotonin; Substance P; Application effect" @default.
- W3032515983 created "2020-06-05" @default.
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- W3032515983 date "2019-02-15" @default.
- W3032515983 modified "2023-09-23" @default.
- W3032515983 title "Effect of viable bifidobacterium quadruple tablets in the treatment of diarrhea induced irritable bowel syndrome and its effect on serum 5-serotonin and substance P" @default.
- W3032515983 doi "https://doi.org/10.3760/cma.j.issn.1007-1245.2019.04.049" @default.
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