FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3032520009> ?p ?o ?g. }

• W3032520009 abstract "Abstract The human brain selectively stores knowledge of the world to optimise future behaviour, automatically rehearsing, contextualising or discarding information to create a robust record of experiences. Storage or forgetting evolves over time, particularly during sleep. We have previously shown that dopamine given in the form of L-DOPA tablets improves long-term memory in Parkinson’s disease, but only when given overnight. L-DOPA is already prescribed widely with a good safety profile and could potentially be rapidly repurposed to improve cognitive performance and improve quality of life in, for example, early Alzheimer’s Disease, if we understood the best time of day to prescribe. Therefore, we sought to test how dopamine shaped long-term memory formation before and during sleep in a double-blind randomised placebo-controlled cross-over trial of healthy older adults (n = 35). We administered L-DOPA after word-list learning to be active during repeat exposure to a proportion of the words and during subsequent nocturnal sleep. Nocturnal dopamine accelerated forgetting for words presented once but it did not affect memory for words presented twice. During slow wave sleep, L-DOPA also increased spindle amplitude around slow oscillation peaks. Larger dopamine-induced difference in word memory was associated with a larger increase in spindle amplitude. Dopamine-dependent memory processing may therefore modulate spindles dependent on slow-oscillation phase. Further, overnight dopamine increased total slow wave sleep duration by approximately 11%. This pharmaceutical modification of slow wave sleep may have potential health-enhancing benefits in old age that could include cognitive enhancement and Alzheimer’s prevention. One Sentence Summary Dopamine before sleep promotes forgetting of weak memory traces associated with increased spindle amplitude around the peak of a slow oscillations." @default.
• W3032520009 created "2020-06-05" @default.
• W3032520009 creator A5000441741 @default.
• W3032520009 creator A5001485961 @default.
• W3032520009 creator A5006606193 @default.
• W3032520009 creator A5007694269 @default.
• W3032520009 creator A5009438919 @default.
• W3032520009 creator A5011151572 @default.
• W3032520009 creator A5023998685 @default.
• W3032520009 creator A5027490505 @default.
• W3032520009 creator A5032756588 @default.
• W3032520009 creator A5036013156 @default.
• W3032520009 creator A5046112755 @default.
• W3032520009 creator A5059818762 @default.
• W3032520009 creator A5060460457 @default.
• W3032520009 creator A5067899834 @default.
• W3032520009 creator A5069670951 @default.
• W3032520009 creator A5073624390 @default.
• W3032520009 creator A5087106961 @default.
• W3032520009 date "2020-05-25" @default.
• W3032520009 modified "2023-09-27" @default.
• W3032520009 title "Dopamine-gated memory selection during slow wave sleep" @default.
• W3032520009 cites W1531988156 @default.
• W3032520009 cites W1539830142 @default.
• W3032520009 cites W1808158081 @default.
• W3032520009 cites W1920095995 @default.
• W3032520009 cites W1969466259 @default.
• W3032520009 cites W1971392964 @default.
• W3032520009 cites W1973117088 @default.
• W3032520009 cites W1973351114 @default.
• W3032520009 cites W1977249777 @default.
• W3032520009 cites W1989055997 @default.
• W3032520009 cites W1992222048 @default.
• W3032520009 cites W1992856299 @default.
• W3032520009 cites W1996885314 @default.
• W3032520009 cites W2002407874 @default.
• W3032520009 cites W2002509975 @default.
• W3032520009 cites W2008609885 @default.
• W3032520009 cites W2011882079 @default.
• W3032520009 cites W2014295524 @default.
• W3032520009 cites W2017814058 @default.
• W3032520009 cites W2036129588 @default.
• W3032520009 cites W2040751411 @default.
• W3032520009 cites W2043427320 @default.
• W3032520009 cites W2043527309 @default.
• W3032520009 cites W2047919057 @default.
• W3032520009 cites W2048397695 @default.
• W3032520009 cites W2051716212 @default.
• W3032520009 cites W2054492267 @default.
• W3032520009 cites W2054727733 @default.
• W3032520009 cites W2056758352 @default.
• W3032520009 cites W2060322330 @default.
• W3032520009 cites W2061085260 @default.
• W3032520009 cites W2061716020 @default.
• W3032520009 cites W2067886794 @default.
• W3032520009 cites W2070250157 @default.
• W3032520009 cites W2072515387 @default.
• W3032520009 cites W2077689316 @default.
• W3032520009 cites W2084615226 @default.
• W3032520009 cites W2086162146 @default.
• W3032520009 cites W2107665951 @default.
• W3032520009 cites W2122568884 @default.
• W3032520009 cites W2127373801 @default.
• W3032520009 cites W2127986203 @default.
• W3032520009 cites W2128435210 @default.
• W3032520009 cites W2128495200 @default.
• W3032520009 cites W2141845152 @default.
• W3032520009 cites W2143017058 @default.
• W3032520009 cites W2143721596 @default.
• W3032520009 cites W2152585727 @default.
• W3032520009 cites W2156970383 @default.
• W3032520009 cites W2163225965 @default.
• W3032520009 cites W2169200398 @default.
• W3032520009 cites W2218418953 @default.
• W3032520009 cites W2262396283 @default.
• W3032520009 cites W2403111963 @default.
• W3032520009 cites W2555205531 @default.
• W3032520009 cites W2560854494 @default.
• W3032520009 cites W2594807028 @default.
• W3032520009 cites W2611695796 @default.
• W3032520009 cites W2735226312 @default.
• W3032520009 cites W2744751690 @default.
• W3032520009 cites W2766300336 @default.
• W3032520009 cites W2775812132 @default.
• W3032520009 cites W2897061357 @default.
• W3032520009 cites W2900540488 @default.
• W3032520009 cites W2900696043 @default.
• W3032520009 cites W2911432682 @default.
• W3032520009 cites W2923500540 @default.
• W3032520009 cites W2941554531 @default.
• W3032520009 cites W2953009208 @default.
• W3032520009 cites W2958190922 @default.
• W3032520009 cites W2969572675 @default.
• W3032520009 cites W3206240530 @default.
• W3032520009 cites W4247532959 @default.
• W3032520009 cites W4376595421 @default.
• W3032520009 doi "https://doi.org/10.1101/2020.05.23.112375" @default.
• W3032520009 hasPublicationYear "2020" @default.
• W3032520009 type Work @default.
• W3032520009 sameAs 3032520009 @default.

• next