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- W3032527505 abstract "The etiology of multiple myeloma(MM) is closely related to bone marrow microenvironment, whereas the mechanism still remains unknown. In recent years, bone marrow microenvironment has been considered as a promising therapy target, especially focusing on soluble cytokines and angiogenesis. Although some progression has been achieved, drug resistance of MM remains unsolved and MM is still incurable. MM is characterized by general immune suppression which could lead to susceptibility to infection and tumor progression. Studies also show that novel drugs, such as bortezomib and thalidomide are able to regulate the immunne system. Those findings highlight the crucial role of dysregulated immunity cells in MM. Exosomes, osteoclasts, myeloid-derived suppressor cells (MDSC) and adipocytes are all capable of suppressing the immunne system, as well as participating the formation of immunosuppressive microenvironment of MM. The expression level of exosomes, adipocytes and MDSC are elevated in MM patients and might correlate with the progression and prognosis of MM. In this review, we will focus on the role of exosomes, adipocytes, osteoclasts, and MDSC in the progression of MM and their potential as novel therapy targets.Key words: Multiple myeloma; Bone marrow; Tumor microenvironment; Suppressor factors, immunologic; Molecular targeted therapy" @default.
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- W3032527505 date "2017-05-20" @default.
- W3032527505 modified "2023-09-23" @default.
- W3032527505 title "Research advance in role of bone marrow microenvironment on pathogenesis of multiple myeloma" @default.
- W3032527505 doi "https://doi.org/10.3760/cma.j.issn.1673-419x.2017.03.010" @default.
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