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- W3032545371 abstract "Abstract Noncoding Y RNAs are abundant in animal cells and present in many bacteria. These RNAs are bound and stabilized by Ro60, a ring-shaped protein that is a target of autoantibodies in patients with systemic lupus erythematosus. Studies in bacteria revealed that Y RNA tethers Ro60 to a ring-shaped exoribonuclease, forming a double-ringed RNP machine specialized for structured RNA degradation. In addition to functioning as a tether, the bacterial RNA gates access of substrates to the Ro60 cavity. To identify roles for Y RNAs in mammals, we used CRISPR to generate mouse embryonic stem cells lacking one or both of the two murine Y RNAs. Despite reports that animal cell Y RNAs are essential for DNA replication, cells lacking these RNAs divide normally. However, Ro60 levels are reduced, revealing that Y RNA binding is required for Ro60 to accumulate to wild-type levels. Y RNAs regulate the subcellular location of Ro60, since Ro60 is reduced in the cytoplasm and increased in nucleoli when Y RNAs are absent. Last, we show that Y RNAs tether Ro60 to diverse effector proteins to generate specialized RNPs. Together, our data demonstrate that the roles of Y RNAs are intimately connected to that of their Ro60 partner." @default.
- W3032545371 created "2020-06-05" @default.
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- W3032545371 creator A5036218550 @default.
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- W3032545371 date "2020-05-29" @default.
- W3032545371 modified "2023-10-12" @default.
- W3032545371 title "Noncoding Y RNAs regulate the levels, subcellular distribution and protein interactions of their Ro60 autoantigen partner" @default.
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- W3032545371 doi "https://doi.org/10.1093/nar/gkaa414" @default.
- W3032545371 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7337961" @default.
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- W3032545371 hasPublicationYear "2020" @default.
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