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• W3032549008 abstract "Severe and recurrent infections of the respiratory tract in early childhood constitute major risk factors for the development of bronchial hyper-responsiveness and obstructive respiratory diseases in later life. In the first years of life, the vast majority of respiratory tract infections (RTI) leading to wheezing and asthma are of a viral origin and severity and recurrence are the consequence of a greater exposure to infectious agents in a period when the immune system is still relatively immature. Therefore, boosting the efficiency of the host immune response against viral infections seems to be a rational preventative approach. In the last decades it has been demonstrated that living in farm environments, i.e. early-life exposure to microbes, may reduce the risk of allergic and infectious disorders, increasing the immune response efficacy. These findings have suggested that treatment with bacterial lysates could promote a nonspecific immunomodulation useful in the prevention of recurrent RTIs and of wheezing inception and persistence. Experimental and clinical studies showing the reduction of RTI frequency and severity in childhood and elucidating the involved mechanisms can support this hypothesis." @default.
• W3032549008 created "2020-06-05" @default.
• W3032549008 creator A5024611057 @default.
• W3032549008 creator A5025407638 @default.
• W3032549008 creator A5030963957 @default.
• W3032549008 creator A5041972769 @default.
• W3032549008 creator A5054568679 @default.
• W3032549008 date "2020-05-29" @default.
• W3032549008 modified "2023-10-12" @default.
• W3032549008 title "Viral infections and wheezing–asthma inception in childhood: is there a role for immunomodulation by oral bacterial lysates?" @default.
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