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- W3032561282 abstract "目的 探讨蛋白激酶C(PKC)信号转导通路在缺氧诱导视网膜色素上皮(RPE)细胞血管内皮生长因子(VEGF)表达中的作用.方法在细胞培养液内加入CoCl2溶液以模拟缺氧环境,培养RPE细胞0.5、48 h后,用免疫荧光法检测人RPE细胞内PKC的表达.将PKC激动剂佛波醇-12-豆蔻酰-13乙酸(PMA)及PKC抑制剂Chelerythrine分别加入人RPE细胞培养液,在缺氧状态下分别培养6、12、24 h后,用ELISA检测各组RPE细胞中VEGF的表达.对照组为常氧状态下培养的RPE细胞.结果免疫荧光染色显示缺氧及常氧状态下,RPE细胞浆及胞核内均有PKC的表达.PKC激动剂PMA可增强缺氧状态下RPE细胞对VEGF的表达,而PKC抑制剂Chelerythrine可减弱缺氧状态下RPE细胞对VEGF的表达.结论缺氧诱导VEGF在RPE细胞中的表达,其信号传导途径部分是通过PKC通路实现的。" @default.
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- W3032561282 date "2005-08-15" @default.
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- W3032561282 title "Effect of PKC signal transduction pathway on expression of VEGF in human RPE cells under hypoxia" @default.
- W3032561282 doi "https://doi.org/10.3760/cma.j.issn.2095-0160.2005.04.003" @default.
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