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- W3032567701 abstract "ObjectiveTo analyze the clinical features and prognosis in adult Chinese patients with anti-γ-aminobutyric acid B receptor (GABA-BR) encephalitis.MethodsWe reviewed the clinical manifestations, cerebrospinal fluid (CSF) examinations, brain magnetic resonance imaging and prognosis of 12 patients who were diagnosed as anti-GABA-BR encephalitis in Capital Medical University Xuanwu Hospital from March 2013 to December 2015.ResultsThe major clinical features of anti-GABA-BR encephalitis patients included seizures (12/12), cognitive disorder (10/12), psychiatric symptoms (10/12), sleep disorders (3/12), visual hallucination (2/12), involuntary movements (2/12), decreased consciousness (3/12), cerebellar signs (2/12), fever (2/12). GABA-BR-antibody was positive in CSF and serum of all the patients. Electroencephalogram revealed epileptic discharges in 4/12 patients. Brain MRl showed abnormal signal in up to 9/12 patients, located in the hippocampus, temporal lobes, thalamus and periventricular area.PET or SPECT indicated hypometabolism in 5/6 patients. After the average of fourteen months follow-up, 9/12 patients had good prognosis, 3 patients did not. Of 3 patients with poor outcome, 2 had small cell lung cancer.ConclusionsThe predominant clinical features of the anti-GABA-BR encephalitis are seizures, cognitive disorder and psychiatric symptoms. The lesions are not only located in limbic system. Early diagnosis and immune modulation may provide a good outcome.Key words: Cerebrospinal fluid; Electroencephalogram; Magnetic resonance imaging; Anti-γ-aminobutyric acid B receptor encephalitis" @default.
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- W3032567701 date "2016-06-08" @default.
- W3032567701 modified "2023-09-24" @default.
- W3032567701 title "The characteristics of clinical manifestations in patients with anti-γ-aminobutyric acid B receptor encephalitis" @default.
- W3032567701 doi "https://doi.org/10.3760/cma.j.issn.1006-7876.2016.06.004" @default.
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