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- W3032569310 abstract "Objective To explore the effects of glycyrrhizinate on apoptosis of hepatocytes in the rats with acute liver failure.Methods Sixty healthy female Wistar rats were randomly divided into 3 groups:experimental group,control group,and normal control group (n =20 in each group).The rats were injected intraperitoneally with D-galactosamine (D-Gal) and lipopolysaccharide (LPS) to create the model of acute liver failure.Three h prior to the injection,the rats in experimental group were intragastrically administered diammonium glycyrrhizinate enteric-coated capsules.Enzyme linked immunosorbent assay (ELISA) and TdT-mediated dUTP nick end labeling (TUNEL) were carried out to detect serum tumor necrosis factor-α (TNF-α) and apoptotic cells of the rats at different time points after injection respectively.Results In experiment and control groups,TUNEL-positive cells appeared at 4 h and 6 h after injection respectively,and reached a peak at 12 h synchronously.The apoptotic index in the experiment group was (5.23 ± 0.28) ％,significantly lower than in the control group [(29.46 ± 0.97) ％] (P ＜ 0.05).In experiment and control groups,the serum TNF-α was increased at 2 h and reached a peak at 8 h after injection synchronously.The serum TNF-α in the experiment group was (510.78 ±93.68) μg/L,significantly different from that in the control group [(532.53 ± 89.77) μg/L] (P ＞ 0.05).Conclusion Glycyrrhizinate enteric-coated capsules can reduce apoptosis of hepatocytes in rats with acute liver failure,which is not achieved by reducing the concentrations of TNF-α in serum.Key words: Acute liver failure; Glycyrrhizinate; Apoptosis; Tumor necrosis factor-α" @default.
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- W3032569310 date "2014-05-08" @default.
- W3032569310 modified "2023-09-24" @default.
- W3032569310 title "Effects of glycyrrhizinate on apoptosis of hepatocytes in rat acute liver failure model" @default.
- W3032569310 doi "https://doi.org/10.3760/cma.j.issn.1001-9030.2014.05.025" @default.
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