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• W3032587714 abstract "ObjectiveTo compare the discursion of endothelial function and metabolism in obese isolated impaired fasting glucose (I-IFG ) and isolated impaired glucose tolerance(I-IGT).MethodsSixty cases of I-IFG(group C ) including obesity(group C2;32 cases) and no-obesity (group C1;28cases) and 83 cases of I-IGT(group D ) including obesity(group D2;42 cases) and no-obesity (group D1:41cases) were compared to 142 cases of normal glucose tolerance (group N ) including obesity(group N2;67 cases) and no-obesity (group N1;75 cases). All cases were detected glucose and insulin with oral glucose tolerance test and insulin release test. Fasting venous blood of all samples were obtained to measure the levels of fasting of blood lipids, free fatty acids(FFA), adiponectin (APN), high-sensitivity C-reactive protein (hs-CRP)and serum endothelin-1(SET-1), and urine endothelin-1 (UET-1) and urea-microalbumin(MUA) after collecting urina sanguinis. To be measured waistline, blood pressure, height and weight, and the arteria brachialis diameter was tested at least and after arteria brachialis elevated pressure and glycergl trintrate. To calculate main arterial blood pressure(MAP), area under curve of glucose(glu AUC), area under curve of insulin (INSAUC), second-phase area under curve of insulin(INSAUC two), ratio of the net increment of insulin to plasma glucose at 20 min (△I20/△G20), insulin resistance index(HOMA-IR)and index of pancreatic islets secretion function (HOMA-β).ResultsIt is significant difference between groups D and C, and between groups D1 and C1 in hs-CRP, SET, UET(P<0.05 or P<0.01) after adjusting sex and age. It is significant difference between groups D2 and C2 in Hs-CRP(P<0.05 ). Meanwhile between groups D and C in FPG, 2 h PG, glu AUC, HOMA-β, INS120 and △I20/△G20 (P<0.05 or P<0.01), between groups D1 and C1 in FPG, glu AUC, 2 h PG, HOMA-IR, HOMA-β, INS120, INSAUC, INSAUC two and △I20/△G20(P<0.05 or P<0.01), between group D2 and group C2 in MAP, FPG, HOMA-β, 2 h PG and INS120(P<0.05).ConclusionsTo compare to the patients with I-IFG, the endothelial dysfunction which occurs in macrovacular is found and it's more serious which occurs in microvacular in the non-obese of I-IGT, but more serious which occurred in macrovacular in the obese of I-IGT; blood pressure increased in the obese of I-IFG; dysglycemia is more serious but lesser in insulin secretion impairment in I-IGT, and early phase insulin secretion impairment is more serious in the non-obese of I-IGT; insulin resistance is more serious in the obese than in the non-obese of I-IFG and I-IGT, and insulin resistance is more serious in the non-obese of I-IGT who occure hyperinsulinemia in second-phase insulin secretion.Key words: Glucose intolerance/CO/PA/ME; Obesity/CO/PA/ME; Endothelins/ME" @default.
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• W3032587714 date "2015-09-20" @default.
• W3032587714 modified "2023-09-26" @default.
• W3032587714 title "Comparison the discursion of endothelial function and metabolism in obese isolated impaired fasting glucose and isolated impaired glucose tolerance" @default.
• W3032587714 doi "https://doi.org/10.3760/cma.j.issn.1008-1372.2015.09.011" @default.
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