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- W3032590636 abstract "目的 探讨白藜芦醇单独及其与氟尿嘧啶(5-Fu)联合应用对小鼠移植性肝癌的抑制作用.方法利用小鼠移植性肝癌H22模型研究白藜芦醇的体内抑瘤作用以及其对氟尿嘧啶抑瘤作用的影响.结果白藜芦醇治疗组能不同程度抑制小鼠肝脏移植瘤的生长,10.0 mg/kg和15 mg/kg的白藜芦醇治疗时抑瘤率分别为36.6%和49.3%,与对照组比较有明显差异(P＜0.01);同时发现白藜芦醇与氟尿嘧啶合用能增加氟尿嘧啶的抑瘤率,单用20 mg/kg或10 mg/kg的氟尿嘧啶,抑瘤率分别为53.1%,43.8%,而合用10 mg/kg的白藜芦醇后抑瘤率分别为77.3%、72.7%,两者有显著性差异,且无明显的毒性反应.结论白藜芦醇能增强氟尿嘧啶的抗癌作用,降低其毒性;白藜芦醇作为生化调节剂可能用于肿瘤联合化疗。" @default.
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- W3032590636 date "2004-10-28" @default.
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- W3032590636 title "Therapeutic effects of resveratrol in combination with 5-Fu on hepatocellular carcinoma in mice" @default.
- W3032590636 doi "https://doi.org/10.3760/cma.j.issn.1007-8118.2004.10.015" @default.
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