Matches in SemOpenAlex for { <https://semopenalex.org/work/W3032593778> ?p ?o ?g. }
- W3032593778 endingPage "1678" @default.
- W3032593778 startingPage "1678" @default.
- W3032593778 abstract "Background: Endothelial progenitor cells (EPCs) have the potential to protect against atherothrombotic event occurrences. There are no data to evaluate the impact of cilostazol on EPC levels in high-risk patients. Methods: We conducted a randomized, double-blind, placebo-controlled trial to assess the effect of adjunctive cilostazol on EPC mobilization and platelet reactivity in patients with acute myocardial infarction (AMI). Before discharge, patients undergoing percutaneous coronary intervention (PCI) were randomly assigned to receive cilostazol SR capsule (200-mg) a day (n = 30) or placebo (n = 30) on top of dual antiplatelet therapy (DAPT) with clopidogrel and aspirin. Before randomization (baseline) and at 30-day follow-up, circulating EPC levels were analyzed using flow cytometry and hemostatic measurements were evaluated by VerifyNow and thromboelastography assays. The primary endpoint was the relative change in EPC levels between baseline and 30-day. Results: At baseline, there were similar levels of EPC counts between treatments, whereas patients with cilostazol showed higher levels of EPC counts compared with placebo after 30 days. Cilostazol versus placebo treatment displayed significantly higher changes in EPC levels between baseline and follow-up (ΔCD133+/KDR+: difference 216%, 95% confidence interval (CI) 44~388%, p = 0.015; ΔCD34+/KDR+: difference 183%, 95% CI 25~342%, p = 0.024). At 30-day follow-up, platelet reactivity was lower in the cilostazol group compared with the placebo group (130 ± 45 versus 169 ± 62 P2Y12 Reaction Unit, p = 0.009). However, there were no significant correlations between the changes of EPC levels and platelet reactivity. Conclusion: Adjunctive cilostazol on top of clopidogrel and aspirin versus DAPT alone is associated with increased EPC mobilization and decreased platelet reactivity in AMI patients, suggesting its pleiotropic effects against atherothrombotic events (NCT04407312)." @default.
- W3032593778 created "2020-06-05" @default.
- W3032593778 creator A5030301889 @default.
- W3032593778 creator A5034107357 @default.
- W3032593778 creator A5037954844 @default.
- W3032593778 creator A5047235637 @default.
- W3032593778 creator A5048651693 @default.
- W3032593778 creator A5062154298 @default.
- W3032593778 creator A5086664717 @default.
- W3032593778 date "2020-06-01" @default.
- W3032593778 modified "2023-10-16" @default.
- W3032593778 title "Adjunctive Cilostazol to Dual Antiplatelet Therapy to Enhance Mobilization of Endothelial Progenitor Cell in Patients with Acute Myocardial Infarction: A Randomized, Placebo-Controlled EPISODE Trial" @default.
- W3032593778 cites W140787630 @default.
- W3032593778 cites W1527614413 @default.
- W3032593778 cites W1733070489 @default.
- W3032593778 cites W1868589471 @default.
- W3032593778 cites W1966268314 @default.
- W3032593778 cites W1988126593 @default.
- W3032593778 cites W1988212011 @default.
- W3032593778 cites W1990018236 @default.
- W3032593778 cites W2000104976 @default.
- W3032593778 cites W2006052369 @default.
- W3032593778 cites W2015044192 @default.
- W3032593778 cites W2031314616 @default.
- W3032593778 cites W2038602682 @default.
- W3032593778 cites W2052341105 @default.
- W3032593778 cites W2057077579 @default.
- W3032593778 cites W2073058859 @default.
- W3032593778 cites W2076921060 @default.
- W3032593778 cites W2094999457 @default.
- W3032593778 cites W2096151264 @default.
- W3032593778 cites W2103317822 @default.
- W3032593778 cites W2104660435 @default.
- W3032593778 cites W2105523329 @default.
- W3032593778 cites W2112711017 @default.
- W3032593778 cites W2122779695 @default.
- W3032593778 cites W2140501627 @default.
- W3032593778 cites W2161774213 @default.
- W3032593778 cites W2169387542 @default.
- W3032593778 cites W2582566182 @default.
- W3032593778 cites W2615170291 @default.
- W3032593778 cites W2683639332 @default.
- W3032593778 cites W27443843 @default.
- W3032593778 cites W2747317772 @default.
- W3032593778 cites W2747484920 @default.
- W3032593778 cites W2752033985 @default.
- W3032593778 cites W2754054868 @default.
- W3032593778 cites W2767288835 @default.
- W3032593778 cites W2769699028 @default.
- W3032593778 cites W2772269597 @default.
- W3032593778 cites W2772646551 @default.
- W3032593778 cites W2793448886 @default.
- W3032593778 cites W2885682912 @default.
- W3032593778 cites W2907776863 @default.
- W3032593778 cites W2992606110 @default.
- W3032593778 doi "https://doi.org/10.3390/jcm9061678" @default.
- W3032593778 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7356664" @default.
- W3032593778 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32492942" @default.
- W3032593778 hasPublicationYear "2020" @default.
- W3032593778 type Work @default.
- W3032593778 sameAs 3032593778 @default.
- W3032593778 citedByCount "1" @default.
- W3032593778 countsByYear W30325937782021 @default.
- W3032593778 crossrefType "journal-article" @default.
- W3032593778 hasAuthorship W3032593778A5030301889 @default.
- W3032593778 hasAuthorship W3032593778A5034107357 @default.
- W3032593778 hasAuthorship W3032593778A5037954844 @default.
- W3032593778 hasAuthorship W3032593778A5047235637 @default.
- W3032593778 hasAuthorship W3032593778A5048651693 @default.
- W3032593778 hasAuthorship W3032593778A5062154298 @default.
- W3032593778 hasAuthorship W3032593778A5086664717 @default.
- W3032593778 hasBestOaLocation W30325937781 @default.
- W3032593778 hasConcept C126322002 @default.
- W3032593778 hasConcept C142724271 @default.
- W3032593778 hasConcept C164705383 @default.
- W3032593778 hasConcept C168563851 @default.
- W3032593778 hasConcept C204787440 @default.
- W3032593778 hasConcept C27081682 @default.
- W3032593778 hasConcept C2777628954 @default.
- W3032593778 hasConcept C2779820409 @default.
- W3032593778 hasConcept C2780400711 @default.
- W3032593778 hasConcept C42219234 @default.
- W3032593778 hasConcept C500558357 @default.
- W3032593778 hasConcept C71924100 @default.
- W3032593778 hasConceptScore W3032593778C126322002 @default.
- W3032593778 hasConceptScore W3032593778C142724271 @default.
- W3032593778 hasConceptScore W3032593778C164705383 @default.
- W3032593778 hasConceptScore W3032593778C168563851 @default.
- W3032593778 hasConceptScore W3032593778C204787440 @default.
- W3032593778 hasConceptScore W3032593778C27081682 @default.
- W3032593778 hasConceptScore W3032593778C2777628954 @default.
- W3032593778 hasConceptScore W3032593778C2779820409 @default.
- W3032593778 hasConceptScore W3032593778C2780400711 @default.
- W3032593778 hasConceptScore W3032593778C42219234 @default.
- W3032593778 hasConceptScore W3032593778C500558357 @default.
- W3032593778 hasConceptScore W3032593778C71924100 @default.
- W3032593778 hasIssue "6" @default.
- W3032593778 hasLocation W30325937781 @default.