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- W3032604022 abstract "Objective To investigate the expression of steroid receptor coactivator-3 (SRC-3) in human hepatocellular carcinoma and its relation with the clinicopathologic characteristics of the carcinoma.Methods Immunohistochemistry and reverse transcriptase-polymerase chain reaction (RT-PCR) were used to detect the level of protein expression and mRNA tanscription of SRC-3 in hepatocellular carcinoma tissues and the paired paratumorous liver (PTL) tissues from 94 patients with hepatocellular carcinoma.By combining with clinical features of these patients,the relationship between SRC-3 expression and clinieopathologic characteristics was studied statistically.Results Immunohistochemistry showed that the positive expression rate of SRC-3 protein was higher in hepatocellular carcinoma tissues than in their paired PTL tissues (55.3％ vs.10.6％,P ＜0.05).SRC-3 mRNA transcription level in hepatocellular carcinoma tissues was significantly higher than that in the PTL tissues (P ＜ 0.05).The clinicopathologic evaluation revealed that the higher protein expression and mRNA transcription level of SRC-3 in hepatocellular carcinoma tissues was correlated with hepatitis B virus (HBV) infection,serum α-fetoprotein levels and pathologic grade (P ＜ 0.05).Conclusion SRC-3 is overexpressed in hepatocellular carcinoma and closely correlated with the clinicopathologic features of the carcinoma.Key words: Carcinoma, hepatocellular; Steroid receptor coactivator-3" @default.
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- W3032604022 date "2014-01-08" @default.
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- W3032604022 title "Expression of steroid receptor coactivator-3 expression in hepatocellular carcinoma and its clinicopathological significance" @default.
- W3032604022 doi "https://doi.org/10.3760/cma.j.issn.1001-9030.2014.01.054" @default.
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