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- W3032606985 abstract "ObjectiveTo explore the factors associated with distant metastasis after intensity-modulated radiotherapy (IMRT) in patients with nasopharyngeal carcinoma (NPC), and to provide evidence for new clinic strategies of NPC.MethodsA retrospective analysis of 645 NPC patients at three treatment centers in Guangxi Zhuang Autonomous Region from January 2009 to December 2011 was performed. All patients had untreated, non-metastatic NPC prior to receiving IMRT. The Kaplan-Meier method was used to evaluate survival outcome, and the log-rank test was used to compare survival differences. Univariate analysis and Cox proportional hazard analysis were performed to explore failure patterns and risk factors of distant metastasis after radiotherapy.ResultsOf the 645 patients, the 5-year distant metastasis rate was 17.5%(113/645). The median metastatic age was 47 years (20-74 years), and the median metastatic time was 24 months after IMRT (6-79 months). The 5-year overall survival rate (OS) was 84.2%, the 5-year recurrence-free survival rate (LRFS) was 90.1%, and the 1-year, 3-year, and 5-year distant metastasis-free survival (DMFS) rates were 96.6%, 87.4% and 82.8%, respectively. Univariate and multivariate analysis showed that N staging, residual cervical lymph node at the end of radiotherapy were independent prognostic factors for DMFS (P<0.05).ConclusionsRadiotherapy combined with chemotherapy can reduce the incidence of distant metastasis after IMRT. The risk of distant metastasis after IMRT was positively correlated with N staging. Remaining of residual cervical lymph node lesion three months after IMRT was a risk factor for poor prognosis A more reasonable intervention strategy needs to be further explored.Key words: IMRT; NPC; Distant metastasis" @default.
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- W3032606985 date "2018-06-30" @default.
- W3032606985 modified "2023-09-27" @default.
- W3032606985 title "Failure patterns of distant metastasis after intensity-modulated radiotherapy in patients with nasopharyngeal carcinoma" @default.
- W3032606985 doi "https://doi.org/10.3760/cma.j.issn.2096-5400.2018.01.006" @default.
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