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- W3032626349 abstract "ObjectiveTo improve the understanding and reduce the misdiagnosis of histiocytic necrotizing lymphadenitis (HNL) by discussed the clinical characteristics, pathogeny and diagnosis of HNL.MethodsClinical data of 51 patients who were diagnosed with HNL in Chinese PLA General Hospital from 2008 to 2017 were retrospectively analyzed.All the patients were diagnosed by lymph node biopsy.ResultsThe characteristics of HNL included young onset age with the average age was (25.98±13.53) years old, and the gender prevalence ratio (male to female) was 1∶1.22.Fever, fatigue and joint pain were common symptoms in HNL.Enlarged lymph nodes, hepatospleno-megaly and skin rashes were usually found in HNL patients.The diameter of the enlarged lymph nodes were less than 3 cm with tenderness.Laboratory findings usually indicates leucopenia and anemia, but erythrocyte sedimentation rate, C-reative protein, serum lactate dehydrogenase, alanine transaminase and aspartame transaminase increased significantly.HNL was resistant to antibiotics, but sensitive to glucocorticoids.ConclusionsThe lack of specific clinical manifestationand laboratory test method might lead to the misdiagnosis and missed diagnosis of HNL.Patients with unknown fever, enlarged lymph nodes with pain and leukopenia should be took into consideration of HNL.Key words: Histiocytic necrotizing lymphadenitis; Pathogenesis; Therapy" @default.
- W3032626349 created "2020-06-05" @default.
- W3032626349 creator A5022871374 @default.
- W3032626349 date "2019-12-05" @default.
- W3032626349 modified "2023-09-28" @default.
- W3032626349 title "Clinical analysis of 51 cases of histiocytic necrotizing lymphadenitis" @default.
- W3032626349 doi "https://doi.org/10.3760/cma.j.issn.1673-436x.2019.23.007" @default.
- W3032626349 hasPublicationYear "2019" @default.
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