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- W3032641617 abstract "Objective At present beam orientation selection in intensity-modulated radiotherapy (IMRT) is mainly based on empiric knowledge. This study is to evaluate the feasibility of automated beam angle selection. Methods Genetic algorithm technique which based on beam eye view dose measurement (BEVD-GA) was tested on two clinical cases, including a spine column cancer and a lung eaneer. Three plans were obtained under the following different beam confignrations:five equiangular-spaced beams, five beams with GA-selected, and five beams with BEVD-GA-seleeted beams. Then the dose distribution was compared among the three plans. Results The method, restricting the range of genetic algorithm followed by carrying through genetic operations, not only shortened the optimization time, but also improved the opti-mization effect. For spine column cancer and lung cancer,the best IMRT plans were obtained with BEVD-GA-selected beams, which used automated beam orientation selection. Conclusions Comparing with the conventional manual beam orientation selection, beam orientation optimization which is feasible in IMRT planning may significantly improve the efficiency and result.Key words: Intensity-modulated radiotherapy; Beam orientation optimization; Genetic algorithm; Beam's-eye-view dosimetrics" @default.
- W3032641617 created "2020-06-05" @default.
- W3032641617 creator A5010929537 @default.
- W3032641617 date "2009-09-15" @default.
- W3032641617 modified "2023-09-26" @default.
- W3032641617 title "Improved genetic algorithm in optimization of beam orientation in intensity modulated radiotherapy" @default.
- W3032641617 doi "https://doi.org/10.3760/cma.j.issn.1004-4221.2009.05.409" @default.
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