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- W3032646724 abstract "目的 探讨99锝-亚甲基二膦酸盐(99Tc-MDP,云克)对兔实验性葡萄膜炎的治疗作用.方法 实验兔22只随机分为生理盐水组、地塞米松组、云克组.ELISA法测定实验性葡萄膜炎兔动物模型造模前、造模后5 d、给药治疗后10 d、停药后5 d、4个不同阶段白细胞介素(IL-2)、干扰素(IFN-γ)、肿瘤坏死因子(TNF-α)的血清质量浓度;浊度法及细胞技术池测定不同治疗阶段房水蛋白及房水细胞计数,于不同阶段摘除眼球行组织病理学观察.结果 与生理盐水组比较,地塞米松组及云克组均可使兔血清IL-2、IFN-γ、TNF-α水平和房水细胞计数、房水蛋白质量浓度降低,差异均有统计学意义(P＜0.05),地塞米松组与云克组2组间差异无统计学意义(P＞0.05).地塞米松组及云克组在治疗后眼球的组织病理学显示炎症较治疗前减轻.结论 云克在一定程度上有降低兔实验性葡萄膜炎血清IL-2、IFN-γ、TNF-α质量浓度及房水细胞计数、房水蛋白质量浓度以及减轻眼球炎症的作用。" @default.
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- W3032646724 date "2009-08-10" @default.
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- W3032646724 title "The effect of 99Tc-MDP on experimental autoimmune uveitis in rabbits" @default.
- W3032646724 doi "https://doi.org/10.3760/cma.j.issn.2095-0160.2009.08.007" @default.
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