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- W3032669310 abstract "Objective To observe the effect of Fenofibrate treating Non-proliferation diabetic retinopathy (NPDR).Methods A prospective random controlled study.Totally forty patients (80 eyes) with NPDR were randomized into two groups:Fenofibrate (group A,15g,qd),placebo Vitamin C (group B,0.1g,tid),and all groups were added with Xueshuangtong capsule.They were taken half an hour before meals.The change of ocular fundus,vision,funduscopy,FFA and fundus photography were observed after 28 days.Results There were no significant difference for the items of patients between two groups pre-therapy (x2sex=0.464,P ＞0.05; tage=0.437,tDM condition=0.549,tDR history=0.962,tDM history=0.484,tFbg=0.886,tSc=0.768,tBMI=0.812,tTG=0.924,tLDL=0.834,tsBp=0.956,tDBp=0.647,tGh=0.726,tvision=0.864,P ＞0.05); the visual acuity of total 52 eyes was increased,including 32 eyes (57.1％) of group A,24 eyes (42.9％) of group B.There were statistically significance for visual acuity at the post-therapy day 21 in both groups compared with pre-therapy (x2=5.605,P ＜0.05),and the number of eyes (BCVA＞0.05) was in 38 eyes,including 26 eyes (68.4％) of group A,12 eyes (31.6％) of group B,There were statistically significance between group A and group B (x2=9.264,P ＜0.05).After treatment,the effective rate of fundus lesions of group A was 30.0％,total effective rate 85.0％,while the effective rate of group B was 15.0％,total effective rate was 55.0％; and the results showed that the curative effect of group A was better than that of group B.There were significant difference for the effective rate between groups (x2=8.571,P ＜0.05).Logistic analysis results showed NPDR clinical therapeutic effect and traditional Chinese medicine symptom were negative correlated with age,history and severity (P ＜0.05).Conclusions Fenofibrate can improve the vision of patients with NPDR,the fundus lesions and the traditional Chinese medicine symptoms.The clinical therapeutic effect of NPDR is possibly correlated to age,history and severity.Key words: Fenofibrate; Vision; Non-proliferation diabetic retinopathy; Lipid" @default.
- W3032669310 created "2020-06-05" @default.
- W3032669310 creator A5061076734 @default.
- W3032669310 date "2014-04-10" @default.
- W3032669310 modified "2023-09-24" @default.
- W3032669310 title "Clinical research of fenofibrate in the treatment of Non-proliferation diabetic retinopathy" @default.
- W3032669310 doi "https://doi.org/10.3760/cma.j.issn.1006-4443.2014.04.011" @default.
- W3032669310 hasPublicationYear "2014" @default.
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