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- W3032673784 abstract "Objectives To study the clinical manifestation, pathological features and their correlation in patients with idiopathic IgA nephropathy( IgAN). Methods The clinicopathological data of 210 biopsy - proven cases of IgAN from Jan. 1999 to Jun. 2010 in our hospital were retrospectively analyzed. All the patients exclude secondary IgAN such as lupus nephritis, purpura nephritis, sjogren syndrome, HBV -associated glomerulonephritis.Results There were 210 patients with IgAN in 506 patients who accepted renal biopsy and the frequency of IgAN was 41.5％. 56.2％ patients were male and 43.8 ％ female. The average age of the patients was 28.9 ± 10.3 years old. The incidence of IgAN was the highest in patients at the age of 20 ～ 29 years(59.5％ ). Clinically, chronic nephritis syndrome type was the most common clinical manifestation(39.5％ ,83/210) ,followed by nephritic syndrome (27. 1％ ,57/210) , chronic renal failure( 11.4％ ) ,gross hematuria( 10.9％ ) and latent glomerulonephritis ( 10.9％ ). The pathological types of IgAN included various pathological types of primary glomerular disease. The frequency of focal proliferative type (27.6％ ,58/210) was higher than those of diffuse proliferative type (23.3 ％ ,49/210 ), minor lesion type ( 15.7％, 33/210 ), and early sclerotic type ( 13.8 ％ , 29/210). The IgA fluorescence intensity of + + was the most common seen in IgAN, accounting for 35.2％ and + + + was the next in order, accounting for 31.4％. Immunopathological results showed that merely staining of IgA in mesangial area was in 28 patients, accounting for13.3％. Staining of IgA combined with 1gG was in 6.2％ of 210 patients. Staining of IgA combined with 1gM was in 45.2％. 169 patients had C3 deposit, accounting for 80.5％. Conclusions The high incidence of IgAN occurs on the period of youngs. IgAN has diverse clinical manifestation and pathological changes,the former didnt correspond with the latter completely. The prognosis is associated with pathological changes closely.Early renal biopsy should be performed in the patients who are doubted to be IgAN and appropriate therapy administered according to the pathological features in order to put off the development of chronic kidney diseases.Key words: Glomerulonephritis, IGA" @default.
- W3032673784 created "2020-06-05" @default.
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- W3032673784 date "2011-09-15" @default.
- W3032673784 modified "2023-09-23" @default.
- W3032673784 title "The clinicopathologic analysis of 210 patients with idiopathic IgA nephropathy" @default.
- W3032673784 doi "https://doi.org/10.3760/cma.j.issn.1673-4416.2011.05.007" @default.
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