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- W3032681467 abstract "Objective To investigate the clinical value of serum cccDNA in treatment of chronic hepatitis B (CHB)by adefovir dipivoxil(ADV). Methods 81 patients with CHB were selected and detected for serum cccDNA. All the patients received ADV treatment( 10 mg/d)and were followed-up once every 24 weeks, for four times. They were divided into two groups(positive and negative groups)by detecting serum cccDNA. HBV DNA, HBeAg, and ALT were detected before and after ADV treatment at week 24, 48, 72 and 96. Results There were no significant differences in age and sexual distiction between two groups of cccDNA positive and negative ( P ＞ 0. 05). The median of HBV DNA decreased gradually with the time of treatment, especially in cccDNA negative group. There was significant difference in the decrease of HBeAg at week 48,72,96( P ＜ 0.05), except the time of baseline and week 24( P ＞ 0.05). There was no significant difference in the decrease of ALT at baseline and week 24,48( P ＞ 0.05), except week 72,96( P ＜ 0.05).Conclusions Withprolonging treatment,HBV DNA, HBeAg and ALT decrease faster in cccDNA negative group than in positive group, so serum cccDNA can be seen as a predictive mark when chronic hepatitis B treated by ADV.Key words: Hepatitis B,chronic; cccDNA; Adefovir dipivoxil" @default.
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- W3032681467 date "2010-02-25" @default.
- W3032681467 modified "2023-09-27" @default.
- W3032681467 title "Clinical value of serum cccDNA in the treatment of chronic hepatitis B by adefovir dipivoxil" @default.
- W3032681467 doi "https://doi.org/10.3760/cma.j.issn.1673-4149.2010.01.009" @default.
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