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- W3032688379 abstract "The use of decitabine (DAC) is a standard treatment for patients with myeloidysplastic syndromes (MDS) and it is commonly used for AML patients who are often considered ineligible for standard induction therapy.DAC significantly improved patient outcomes.However, drug resistance was universal.Most patients develop drug resistance within 1.5 years of the treatment and eventually die from disease progress.It was originally thought that demethylation of genes leading to aberrant methylation is the primary mechanism of DAC, and the involvement of the immune mechanism is suspected.This notion has not been demonstrated experimentally.In recent years, basic studies have indicate that DAC can play an immune regulatory mechanism by inducing the re-expression of endogenous retroviruses silenced by methylation.Moreover, DAC has dual clinical effects.It may improve the patient's condition, and it may also increase the risk of disease progression, which may be related to elevated expression of the molecules involved in the induction of immune checkpoints.This provides a theoretical basis for the introduction of immune checkpoint blockers for patients who have failed in the treatment with DAC.The immune mechanisms of decitabine for the treatment of MDS and AML was summarized.The cause of drug resistance and how to overcome DAC resistance were also discussed.Key words: Myeloidysplastic syndromes; Acute myeloid leukemia; Decitabine; Immune checkpoint" @default.
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- W3032688379 date "2018-01-05" @default.
- W3032688379 modified "2023-09-28" @default.
- W3032688379 title "The immune mechanism of decitabine in the treatment of myelodysplastic syndromes and acute myeloid leukemia" @default.
- W3032688379 doi "https://doi.org/10.3760/cma.j.issn.1673-4394.2018.01.021" @default.
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