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- W3032703010 abstract "ObjectiveTo assess efficacy of minocycline for the treatment of Chlamydia trachomatis (C.t) urogenital infection by using different standards.MethodsClinical data were collected from patients with C.t urogenital infection confirmed based on medical history, clinical symptoms and pathological findings in STD clinics of Tianjin Medical University General Hospital between 2006 and 2010, and retrospectively analyzed. Patients were treated with minocycline and then followed up once a month for at least 3 times. Cure was defined as disappearance of clinical symptoms (clinical standard) or absence of C.t in male urethral or female cervical swab samples as shown by indirect immunofluorescence assay (pathogenic standard) at three follow-up visits. Both differences and associations were assessed between cure rates calculated according to the two standards.ResultsFrom 2006 to 2010, a total of 2 638 patients diagnosed with C.t urogenital infection were treated with oral minocycline, and 924 completed three times of follow-up. Of the 924 patients, 784 (84.85%) were considered to be cured based on the clinical standard, and the clinical cure rate was significantly higher than the pathogen clearance rate at the first (69.16% [639/924], χ2 = 58.565, P 0.05). There were no evident associations between the clinical cure rate and the first, second or third pathogen clearance rate (all rc c < 0.1).ConclusionThe therapeutic effect of minocycline on C.t urogenital infection may be overestimated according to the disappearance of symptoms, and in order to objectively evaluate it, pathogenic detection should be carried out once a month for at least 2 times after treatment.Key words: Chlamydia trachomatis; Reproductive tract infections; Minocycline; Efficacy evaluation" @default.
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- W3032703010 date "2016-12-15" @default.
- W3032703010 modified "2023-09-27" @default.
- W3032703010 title "Evaluation of efficacy of minocycline for the treatment of Chlamydia trachomatis urogenital infection by using clinical and pathogenic standards" @default.
- W3032703010 doi "https://doi.org/10.3760/cma.j.issn.0412-4030.2016.12.013" @default.
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