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- W3032714628 abstract "目的 研究干扰素(IFN)β-1b对实验性自身免疫性脑脊髓炎(EAE)小鼠中枢神经系统(CNS)中单核细胞趋化蛋白-1(MCP-1)表达的影响,从趋化因子角度探讨IFN β治疗多发性硬化(MS)的机制.方法 用髓鞘少突胶质细胞糖蛋白35～55多肽加福氏完全佐剂皮下注射免疫C57BL/6小鼠建立EAE模型,干预组(n=12)在免疫当天至免疫后第16天隔H一次皮下注射10 000单位IFN β-1b,对照组(n=12)则同时予1 mLPBS皮下注射.比较两组EAE小鼠的临床表现,并用免疫组织化学及原位杂交技术比较两组EAE脊髓中MCP-1表达及MCP-1 mRNA水平的差异.结果 与对照组相比,IFN β-1b干预组小鼠发病明显延迟,症状明显减轻,同时脊髓中MCP-1的表达及MCP-1 mRNA的水平显著下调. 结论 IFN β-1b可抑制EAE小鼠CNS中趋化因子MCP-1的表达,这可能是其治疗MS的机制之一。" @default.
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- W3032714628 date "2007-03-15" @default.
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- W3032714628 title "Effect of interferon β-1b on chemokine MCP-1 expression in spinal cord of EAE mice" @default.
- W3032714628 doi "https://doi.org/10.3760/cma.j.issn.1671-8925.2007.03.019" @default.
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