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- W3032756118 abstract "Objective To study the effects of sleep deprivation for six-consecutive-day on thyroid function and anti-thyroid antibodies in Wistar rats.Methods Thirty rats aged 3 month healthy Wistar were randomly divided into three groups according to a random number table:sleep deprivation group(SD group),tank cage group (TC group) and control group (CC group),with five females and five males in each group.Sleep deprivation was induced in rats by housing them on small platforms over water.Controls were housed either in tanks with large platforms(TC group) or in normal cage(CC group).Rats in SD group and TC group were placed in 24-hour proposed lighting environment,and rats in SD group were deprived of sleep for 6 consecutive days.Rats in CC group were placed in 12 hours light and 12 hours dark environment.Six days later,all rats were sacrificed,thyroid tissue and blood from femoral artery were saved.Total T3(TT3),totalT4(T4),free T3 (FT3),free T4 (FT4) and thyroid stimulating hormone (TSH) in serum were detected by chemiluminescence immunoassay,and the level of anti-thyroid peroxidase(TPOAb),anti-thyroglobulin (TgAb) and thyroglobulin (Tg) were evaluated by radioimmunoassay.Results TT3 in SD group were significandy higher than that of rats in TC and CC group (all P ＜0.05).Compared with TC and CC group,the concentrations of TT4,FT4 were lower (all P ＜ 0.05),and FT3 and Tg concentrations were a little higher.No significant changes were found in TSH,TPOAb and TgAb among the three groups.Conclusion Six consecutive days of sleep deprivation can influence thyroid function,but can be compensated by transferring more T4 to T3.Key words: Sleep deprivation ; Thyroid function ; Antithyroid antibodies ; Rats" @default.
- W3032756118 created "2020-06-05" @default.
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- W3032756118 date "2014-07-20" @default.
- W3032756118 modified "2023-09-24" @default.
- W3032756118 title "Study on thyroid function and anti-thyroid antibodies changes of Wistar rats during sleep deprivation" @default.
- W3032756118 doi "https://doi.org/10.3760/cma.j.issn.1673-4157.2014.04.003" @default.
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