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- W3032756591 abstract "ObjectiveTo investigate the protective effect of ADP-ribosylation factor 6 inhibitor on acute kidney injury induced by sepsis in mice.MethodsIn February 2018, thirty male BALB/c mice were divided into uninfected group (5 mice), fluconazole group (5 mice), ADP-ribosylation factor 6 inhibitor group (10 mice)(inhibitor group) and saline control group (10 mice)(control group) by random number table method. In fluconazole group, inhibitor group and control group, 1×105 CFU of Candida albicans was injected via tail vein for modeling. The uninfected group was injected with equal volume of saline. After 3 hours, inhibitor group was injected with 1.032 mg ADP-ribosylation factor 6 inhibitor, and fluconazole group was injected with 51 μg fluconazole. The control group were injected with equal volume of saline as inhibitor group. After 24hours, serum creatinine, urea nitrogen were measured by kit method. The mice were clinically scored for sepsis severity according to signs and symptoms after treatment and histopathological changing of kidney tissue were observed and scored according to the damage area of renal cortical with hematoxylin-eosin staining.ResultsThe clinical scores, serum creatinine, urea nitrogen and pathological scores of uninfected group were 0, (0.98±0.38)μmol/L, (9.77±0.36)mmol/L, (0.88±0.30), respectively. The fluconazole group were (0.80±0.84), (1.09±0.51)μmol/L, (9.64±0.17)mmol/L, (1.22±0.270), respectively. The inhibitor group were (2.80±1.32), (1.43±0.50) μmol/L, (12.05±1.20) mmol/L, (2.04±0.55), respectively). The control group were (5.20±1.87), (2.96±1.55) μmol/L, (13.94±1.94) mmol/L, (2.67±0.55). The difference was statistically significant between inhibitor group and the control group both (P<0.05).ConclusionsADP-ribosylation factor 6 inhibitor reduce acute kidney injury induced by sepsis in mice.Key words: ADP-ribosylation factor 6 inhibitor; Sepsis; Acute kidney injury" @default.
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- W3032756591 date "2019-01-15" @default.
- W3032756591 modified "2023-09-25" @default.
- W3032756591 title "Effect of ADP-ribosylation factor 6 inhibitor on acute kidney injury caused by fungal infection induced sepsis" @default.
- W3032756591 doi "https://doi.org/10.3760/cma.j.issn.1000-6702.2019.01.011" @default.
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