Matches in SemOpenAlex for { <https://semopenalex.org/work/W3032789381> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W3032789381 endingPage "292" @default.
- W3032789381 startingPage "289" @default.
- W3032789381 abstract "精神分裂症与中枢多巴胺功能紊乱高度相关，绝大部分抗精神病药通过拮抗多巴胺D2受体改善症状。精神分裂症患者对多巴胺具有高反应性，且精神分裂症发病机制与中脑边缘系统关系密切，背侧纹状体的功能障碍可能是导致精神分裂症症状的首要因素。大部分抗精神病药针对中脑边缘系统的多巴胺通路，相比于第1代抗精神病药，非典型（第2代）抗精神病药显著降低锥体外系副反应，而新研发的抗精神病药具有更多的作用靶点和更精确的分子途径。抗精神病药对多巴胺D2/D3受体占有率与改善症状减轻药物不良反应有关，针对疾病的病理生理机制如何设计出更可靠有效的治疗药物，仍需进一步探索与研究。" @default.
- W3032789381 created "2020-06-05" @default.
- W3032789381 creator A5030568841 @default.
- W3032789381 date "2019-08-05" @default.
- W3032789381 modified "2023-09-23" @default.
- W3032789381 title "The mechanism of dopamine with schizophrenia and antipsychotic drugs treatment" @default.
- W3032789381 doi "https://doi.org/10.3760/cma.j.issn.1006-7884.2019.04.011" @default.
- W3032789381 hasPublicationYear "2019" @default.
- W3032789381 type Work @default.
- W3032789381 sameAs 3032789381 @default.
- W3032789381 citedByCount "0" @default.
- W3032789381 crossrefType "journal-article" @default.
- W3032789381 hasAuthorship W3032789381A5030568841 @default.
- W3032789381 hasConcept C111472728 @default.
- W3032789381 hasConcept C118552586 @default.
- W3032789381 hasConcept C120069818 @default.
- W3032789381 hasConcept C138885662 @default.
- W3032789381 hasConcept C15744967 @default.
- W3032789381 hasConcept C169760540 @default.
- W3032789381 hasConcept C170457331 @default.
- W3032789381 hasConcept C2776412080 @default.
- W3032789381 hasConcept C2780494398 @default.
- W3032789381 hasConcept C3019878999 @default.
- W3032789381 hasConcept C513476851 @default.
- W3032789381 hasConcept C71924100 @default.
- W3032789381 hasConcept C89611455 @default.
- W3032789381 hasConcept C98274493 @default.
- W3032789381 hasConceptScore W3032789381C111472728 @default.
- W3032789381 hasConceptScore W3032789381C118552586 @default.
- W3032789381 hasConceptScore W3032789381C120069818 @default.
- W3032789381 hasConceptScore W3032789381C138885662 @default.
- W3032789381 hasConceptScore W3032789381C15744967 @default.
- W3032789381 hasConceptScore W3032789381C169760540 @default.
- W3032789381 hasConceptScore W3032789381C170457331 @default.
- W3032789381 hasConceptScore W3032789381C2776412080 @default.
- W3032789381 hasConceptScore W3032789381C2780494398 @default.
- W3032789381 hasConceptScore W3032789381C3019878999 @default.
- W3032789381 hasConceptScore W3032789381C513476851 @default.
- W3032789381 hasConceptScore W3032789381C71924100 @default.
- W3032789381 hasConceptScore W3032789381C89611455 @default.
- W3032789381 hasConceptScore W3032789381C98274493 @default.
- W3032789381 hasIssue "4" @default.
- W3032789381 hasLocation W30327893811 @default.
- W3032789381 hasOpenAccess W3032789381 @default.
- W3032789381 hasPrimaryLocation W30327893811 @default.
- W3032789381 hasRelatedWork W14947124 @default.
- W3032789381 hasRelatedWork W1967482642 @default.
- W3032789381 hasRelatedWork W1974070760 @default.
- W3032789381 hasRelatedWork W1985674713 @default.
- W3032789381 hasRelatedWork W2002930196 @default.
- W3032789381 hasRelatedWork W2043111296 @default.
- W3032789381 hasRelatedWork W2043843213 @default.
- W3032789381 hasRelatedWork W2062134604 @default.
- W3032789381 hasRelatedWork W2068057735 @default.
- W3032789381 hasRelatedWork W2079718639 @default.
- W3032789381 hasRelatedWork W2091991835 @default.
- W3032789381 hasRelatedWork W2113742168 @default.
- W3032789381 hasRelatedWork W2492320343 @default.
- W3032789381 hasRelatedWork W2492920410 @default.
- W3032789381 hasRelatedWork W2593492282 @default.
- W3032789381 hasRelatedWork W2804124045 @default.
- W3032789381 hasRelatedWork W2805018640 @default.
- W3032789381 hasRelatedWork W2948002817 @default.
- W3032789381 hasRelatedWork W596408784 @default.
- W3032789381 hasRelatedWork W3115996681 @default.
- W3032789381 hasVolume "52" @default.
- W3032789381 isParatext "false" @default.
- W3032789381 isRetracted "false" @default.
- W3032789381 magId "3032789381" @default.
- W3032789381 workType "article" @default.