Matches in SemOpenAlex for { <https://semopenalex.org/work/W3032792876> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W3032792876 endingPage "828" @default.
- W3032792876 startingPage "823" @default.
- W3032792876 abstract "ObjectiveTo observe the effect of selective cyclooxygenase inhibitor combined with radiation therapy on tumor growth of A549 human lung adenocarcinoma xenograft and further explore the radiosensitization mechanism.MethodsA549 lung adenocarcinoma xenograft tumor models were constructed.When the longest diameter of tumor grew to be 6.0 mm, the mice were randomly divided into four groups: control group, nimesulide group, radiotherapy group and combination group.Nimesulide was dissolved in 0.5% carboxymethylcellulose sodium, given by intragastric administration, and the dose was 60 mg·kg-1·d-1 for 28 days.Single high dose of 10 Gy radiotherapy was given when the longest diameter of tumor grew to be 6.0 mm.The time of tumor growth from 6 mm to 12 mm was observed, growth curve and inhibition rate were calculated by tumor volume.The expressions of proliferating cell nuclear antigen (PCNA), proapoptotic protein Bax and inhibitor of apoptosis protein Bcl-2 in tissues were detected by immunohistochemical method.The cell cycle and apoptosis rate were measured by flow cytometry.ResultsNimesulide combined with radiotherapy significantly inhibited tumor growth in nude mice with lung adenocarcinoma.The time of tumor growth increased from 6 mm to 12 mm was (7.12±0.72) d in control group, (8.34±0.71) d in radiotherapy group, (11.29±0.78) d in nimesulide group and (14.62±0.19) d in combination group.The inhibition rate was 21.2% in radiotherapy group, 18.3% in nimesulide group, 41.7% in combination group.Immunohistochemistry showed that the percentage of positive expression and gray value of PCNA and Bcl-2 in combination group, radiotherapy group, and nimesulide group were lower than those in control group (all P 0.05). The cell distribution in S phase of combination group, radiotherapy group, nimesulide group was lower than that in control group (all P 0.05).ConclusionsNimesulide can inhibit the A549 xenograft tumor growth and enhance the A549 xenograft tumor sensitivity to radiation therapy, which may be related to inhibition of tumor cell growth by inhibiting PCNA expression, and A549 apoptosis induced by inhibiting Bcl-2 expression and enhancing Bax expression, also possibly related with increased cell distribution in G2/M phase and decreased cell number in S phase.Key words: Nimesulide; Radiosensitization; Lung cancer; Proliferation; Apoptosis" @default.
- W3032792876 created "2020-06-05" @default.
- W3032792876 creator A5027090738 @default.
- W3032792876 date "2016-06-05" @default.
- W3032792876 modified "2023-09-23" @default.
- W3032792876 title "Effect of selective COX-2 inhibitor nimesulide on sensitivity of radiation therapy for lung cancer and its mechanism" @default.
- W3032792876 doi "https://doi.org/10.3760/cma.j.issn.1673-436x.2016.11.006" @default.
- W3032792876 hasPublicationYear "2016" @default.
- W3032792876 type Work @default.
- W3032792876 sameAs 3032792876 @default.
- W3032792876 citedByCount "0" @default.
- W3032792876 crossrefType "journal-article" @default.
- W3032792876 hasAuthorship W3032792876A5027090738 @default.
- W3032792876 hasConcept C121608353 @default.
- W3032792876 hasConcept C126322002 @default.
- W3032792876 hasConcept C142724271 @default.
- W3032792876 hasConcept C185592680 @default.
- W3032792876 hasConcept C190283241 @default.
- W3032792876 hasConcept C203014093 @default.
- W3032792876 hasConcept C204232928 @default.
- W3032792876 hasConcept C2776256026 @default.
- W3032792876 hasConcept C2777570176 @default.
- W3032792876 hasConcept C2777714996 @default.
- W3032792876 hasConcept C2779707156 @default.
- W3032792876 hasConcept C2781182431 @default.
- W3032792876 hasConcept C29537977 @default.
- W3032792876 hasConcept C34688535 @default.
- W3032792876 hasConcept C502942594 @default.
- W3032792876 hasConcept C509974204 @default.
- W3032792876 hasConcept C553184892 @default.
- W3032792876 hasConcept C55493867 @default.
- W3032792876 hasConcept C62112901 @default.
- W3032792876 hasConcept C71924100 @default.
- W3032792876 hasConcept C81729549 @default.
- W3032792876 hasConcept C98274493 @default.
- W3032792876 hasConceptScore W3032792876C121608353 @default.
- W3032792876 hasConceptScore W3032792876C126322002 @default.
- W3032792876 hasConceptScore W3032792876C142724271 @default.
- W3032792876 hasConceptScore W3032792876C185592680 @default.
- W3032792876 hasConceptScore W3032792876C190283241 @default.
- W3032792876 hasConceptScore W3032792876C203014093 @default.
- W3032792876 hasConceptScore W3032792876C204232928 @default.
- W3032792876 hasConceptScore W3032792876C2776256026 @default.
- W3032792876 hasConceptScore W3032792876C2777570176 @default.
- W3032792876 hasConceptScore W3032792876C2777714996 @default.
- W3032792876 hasConceptScore W3032792876C2779707156 @default.
- W3032792876 hasConceptScore W3032792876C2781182431 @default.
- W3032792876 hasConceptScore W3032792876C29537977 @default.
- W3032792876 hasConceptScore W3032792876C34688535 @default.
- W3032792876 hasConceptScore W3032792876C502942594 @default.
- W3032792876 hasConceptScore W3032792876C509974204 @default.
- W3032792876 hasConceptScore W3032792876C553184892 @default.
- W3032792876 hasConceptScore W3032792876C55493867 @default.
- W3032792876 hasConceptScore W3032792876C62112901 @default.
- W3032792876 hasConceptScore W3032792876C71924100 @default.
- W3032792876 hasConceptScore W3032792876C81729549 @default.
- W3032792876 hasConceptScore W3032792876C98274493 @default.
- W3032792876 hasIssue "11" @default.
- W3032792876 hasLocation W30327928761 @default.
- W3032792876 hasOpenAccess W3032792876 @default.
- W3032792876 hasPrimaryLocation W30327928761 @default.
- W3032792876 hasRelatedWork W228370499 @default.
- W3032792876 hasRelatedWork W2357118890 @default.
- W3032792876 hasRelatedWork W2360494812 @default.
- W3032792876 hasRelatedWork W2362378512 @default.
- W3032792876 hasRelatedWork W2364981465 @default.
- W3032792876 hasRelatedWork W2373976089 @default.
- W3032792876 hasRelatedWork W2374621059 @default.
- W3032792876 hasRelatedWork W2375405927 @default.
- W3032792876 hasRelatedWork W2381394072 @default.
- W3032792876 hasRelatedWork W2383627533 @default.
- W3032792876 hasRelatedWork W2384389814 @default.
- W3032792876 hasRelatedWork W2391981104 @default.
- W3032792876 hasRelatedWork W2391988068 @default.
- W3032792876 hasRelatedWork W2393512398 @default.
- W3032792876 hasRelatedWork W2399789517 @default.
- W3032792876 hasRelatedWork W3028634060 @default.
- W3032792876 hasRelatedWork W3030231569 @default.
- W3032792876 hasRelatedWork W3030569982 @default.
- W3032792876 hasRelatedWork W3030766920 @default.
- W3032792876 hasRelatedWork W3031077216 @default.
- W3032792876 hasVolume "36" @default.
- W3032792876 isParatext "false" @default.
- W3032792876 isRetracted "false" @default.
- W3032792876 magId "3032792876" @default.
- W3032792876 workType "article" @default.