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- W3032799408 abstract "Objective To evaluate the effects of long-term, low dose rate fission neutron irradiation on lymphocyte subpopulations in peripheral blood of rots. Methods Ninety-six rats were randomly divided into control group and irradiated group exposed to low dose rate fission neutron (252 Cf,0.35 mGy/h) for 20.5 h every day.At days 14,28,42,56 and 70 d after irradiation and 35 d after stopping irradiation, After 8 rats of each group were killed, WBC and lymphocyte subpopulations of CD4+ CD3+,CD8+ CD3+ and CD45RA+/CD161α+ in peripheral blood were estimated respectively. Results Compared with the control group,WBC was reduced significantly at dose of 0.3, 0.4 and 0.5 Gy (P<0.05), and was decreased remarkably at 35 d after stopping irradiation (P<0.01). The rate of CD4+ CD3- was evidently higher compared with control group at doses of 0.1,0.3, 0.4 and 0.5 Gy and 35 d after stopping irradiation (P<0.01, P<0.01 and P < 0.05), and the rate of CD8+ CD3- was obviously higher compared with control group at dose of 0.2 and 0.3 Gy (P<0.05 and P<0.01). On the other hand, the rate of CD4+ CD3+ at dose of 0.1 Gy ( P < 0.01 ) and the rate of CD8+ CD3+ at doses of 0.1 and 0.2 Gy (P <0.05) were higher when compared with control group. At the same time,peripheral blood NK cells(CD161α+ CD45RA-) was increased significantly at doses of 0.2-0.3 Gy, and peripheral blood B cells(CD161α- CD45RA+ ) was reduced remarkably at doses of 0.1-0.5 Gy and 35 d after stopping irradiation compared with the control group. Conclusions Long-term irradiation with low dose rate fission neutron could make TCR (T-cell-receptor) mutant, therefore, WBC, B cells in peripheral blood significantly reduced and NK cells increased. These changes may could not recover at 35 d after stopping irradiation.Key words: Fission neutron; Low dose rate; Lymphocyte subpopulations; Rat" @default.
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- W3032799408 date "2008-10-25" @default.
- W3032799408 modified "2023-09-26" @default.
- W3032799408 title "Effects of low dose rate fission neutron irradiation on the lymphocyte subpopulations of peripheral blood in rats" @default.
- W3032799408 doi "https://doi.org/10.3760/cma.j.issn.0254-5098.2008.05.014" @default.
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