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- W3032803075 abstract "ObjectiveTo study the clinical features of light chain amyloidosis nephropathy (AL-nephropathy), and investigate its laboratory screening indicators.MethodsA total of 119 patients with AL-nephropathy confirmed by renal biopsy in Department of Nephrology, the First Affiliated Hospital of Zhengzhou University from October 2014 to October 2017 were selected. According to the kidney damage staging, the patients were divided into proteinuria group (n=30), nephrotic syndrome group (n=61) and renal insufficiency group (n=28). The clinical data of the patients were retrospectively analyzed.ResultsThere were statistically significant differences in blood pressure, hemoglobin, globulin, erythrocyte sedimentation rate, calcium and phosphorus, blood Kappa chain, immunoglobulin IgG in patients with AL-nephropathy with renal damage at different stages (P<0.05). Combined detection of urinary Bence-Jones protein and blood immunofixation electrophoresis could improve the detection rate of M protein.ConclusionsPatients with AL-nephropathy characterized by nephrotic syndrome often present with low blood immunoglobulin IgG and Kappa chains. Increased anemia, high globulin and rapid erythrocyte sedimentation rate may be risk factors for the progression of renal impairment in AL-nephropathy. A combination of blood immunofixation electrophoresis and urinary Bence-Jones protein is helpful in screening AL-nephropathy. However, the definite diagnosis still depends on renal biopsy.Key words: Light chain amyloidosis; Kidney disease; Clinical features; Screening" @default.
- W3032803075 created "2020-06-05" @default.
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- W3032803075 date "2019-12-10" @default.
- W3032803075 modified "2023-09-23" @default.
- W3032803075 title "Clinical characteristics and screening indexes of light chain amyloidosis nephropathy" @default.
- W3032803075 doi "https://doi.org/10.3760/cma.j.issn.1674-4756.2019.23.002" @default.
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