Matches in SemOpenAlex for { <https://semopenalex.org/work/W3032805218> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W3032805218 abstract "e13544 Background: Hepatitis B virus (HBV) infection in hepatocytes may induce chronic liver damage, which further leads to hepatocellular carcinoma. HBV infection was also reported in other cell types including peripheral blood mononuclear cells (PBMCs). Moreover, epidemiological evidence suggested that HBV infection was associated with various types of cancers. In this study, we investigated whether HBV DNA integration was observed in extrahepatic tumor cells. Methods: The study enrolled thousands of Chinese patients with different types of cancers. Peripheral blood and tumor tissue samples were collected, plasma cfDNA, PBMC gDNA and tumor tissue DNA were extracted. By targeted capture and next-generation sequencing, we sequenced the cancer-related genes and identified HBV DNA integration events in these samples. Moreover, the subtype of HBV captured in the host genome was verified, and the ratio of reads mapped to the HBV genome was calculated. Results: Samples with more than 0.1% of the sequencing reads mapped to the HBV genome were identified as HBV positive cases. Thirty-two liver cancer patients were subtype-b HBV positive, among which 8 tumor samples exhibited HBV genome integration. Three colorectal cancer patients were infected by subtype-c HBV, only one tumor sample carried HBV DNA integration. Two lung cancer patients were shown to be HBV positive; one was infected by subtype-b HBV and the other carried subtype-c HBV. Subtype-b and-c HBV genome was observed in the tumor sample of two cholangiocarcinoma patients, whereas subtype-b HBV DNA was identified in the PBMC of one gastrointestinal stromal cancer patient. Conclusions: HBV genome integration was identified in the tumor cells of lung, colorectal, biliary ducts, and gastrointestinal stromal cancer. The mechanisms by which the HBV genome integrates into these tissues requires further investigation." @default.
- W3032805218 created "2020-06-05" @default.
- W3032805218 creator A5002901852 @default.
- W3032805218 creator A5005196552 @default.
- W3032805218 creator A5011614973 @default.
- W3032805218 creator A5020147975 @default.
- W3032805218 creator A5023632317 @default.
- W3032805218 creator A5040868085 @default.
- W3032805218 creator A5082118972 @default.
- W3032805218 date "2020-05-20" @default.
- W3032805218 modified "2023-09-26" @default.
- W3032805218 title "HBV-human DNA integration in non-hepatic tumors." @default.
- W3032805218 doi "https://doi.org/10.1200/jco.2020.38.15_suppl.e13544" @default.
- W3032805218 hasPublicationYear "2020" @default.
- W3032805218 type Work @default.
- W3032805218 sameAs 3032805218 @default.
- W3032805218 citedByCount "0" @default.
- W3032805218 crossrefType "journal-article" @default.
- W3032805218 hasAuthorship W3032805218A5002901852 @default.
- W3032805218 hasAuthorship W3032805218A5005196552 @default.
- W3032805218 hasAuthorship W3032805218A5011614973 @default.
- W3032805218 hasAuthorship W3032805218A5020147975 @default.
- W3032805218 hasAuthorship W3032805218A5023632317 @default.
- W3032805218 hasAuthorship W3032805218A5040868085 @default.
- W3032805218 hasAuthorship W3032805218A5082118972 @default.
- W3032805218 hasConcept C104317684 @default.
- W3032805218 hasConcept C121608353 @default.
- W3032805218 hasConcept C126322002 @default.
- W3032805218 hasConcept C137061746 @default.
- W3032805218 hasConcept C141231307 @default.
- W3032805218 hasConcept C159047783 @default.
- W3032805218 hasConcept C202751555 @default.
- W3032805218 hasConcept C2522874641 @default.
- W3032805218 hasConcept C2776231280 @default.
- W3032805218 hasConcept C2777382497 @default.
- W3032805218 hasConcept C2778019345 @default.
- W3032805218 hasConcept C2780593183 @default.
- W3032805218 hasConcept C502942594 @default.
- W3032805218 hasConcept C54355233 @default.
- W3032805218 hasConcept C71924100 @default.
- W3032805218 hasConcept C86803240 @default.
- W3032805218 hasConceptScore W3032805218C104317684 @default.
- W3032805218 hasConceptScore W3032805218C121608353 @default.
- W3032805218 hasConceptScore W3032805218C126322002 @default.
- W3032805218 hasConceptScore W3032805218C137061746 @default.
- W3032805218 hasConceptScore W3032805218C141231307 @default.
- W3032805218 hasConceptScore W3032805218C159047783 @default.
- W3032805218 hasConceptScore W3032805218C202751555 @default.
- W3032805218 hasConceptScore W3032805218C2522874641 @default.
- W3032805218 hasConceptScore W3032805218C2776231280 @default.
- W3032805218 hasConceptScore W3032805218C2777382497 @default.
- W3032805218 hasConceptScore W3032805218C2778019345 @default.
- W3032805218 hasConceptScore W3032805218C2780593183 @default.
- W3032805218 hasConceptScore W3032805218C502942594 @default.
- W3032805218 hasConceptScore W3032805218C54355233 @default.
- W3032805218 hasConceptScore W3032805218C71924100 @default.
- W3032805218 hasConceptScore W3032805218C86803240 @default.
- W3032805218 hasLocation W30328052181 @default.
- W3032805218 hasOpenAccess W3032805218 @default.
- W3032805218 hasPrimaryLocation W30328052181 @default.
- W3032805218 hasRelatedWork W14071285 @default.
- W3032805218 hasRelatedWork W15388267 @default.
- W3032805218 hasRelatedWork W17675674 @default.
- W3032805218 hasRelatedWork W19160979 @default.
- W3032805218 hasRelatedWork W20170433 @default.
- W3032805218 hasRelatedWork W21000326 @default.
- W3032805218 hasRelatedWork W3177452769 @default.
- W3032805218 hasRelatedWork W7704036 @default.
- W3032805218 hasRelatedWork W8052306 @default.
- W3032805218 hasRelatedWork W15255855 @default.
- W3032805218 isParatext "false" @default.
- W3032805218 isRetracted "false" @default.
- W3032805218 magId "3032805218" @default.
- W3032805218 workType "article" @default.