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- W3032827813 abstract "目的 对比研究alphagan与timolol对青光眼动物模型的治疗效果,论证alphagan降眼压作用之外的神经保护作用.方法新西兰大耳白兔32只,分为正常对照组和损伤治疗组,损伤治疗组通过急性升高兔眼内压的方法,制成青光眼动物模型,在视网膜缺血前1h分别结膜囊内给予生理盐水、0.5%timolol眼液或0.2%alphagan眼液局部治疗.观察不同治疗对眼压的影响,并在视网膜缺血后血流再灌注7d(下简称缺血再灌注7d),观察图形视网膜电图(P-ERG)b波振幅变化,进行组织形态学观察和视网膜神经节细胞(RGC)计数分析.结果alphagan治疗与timolol治疗相比,具有与timolol相似的降眼压效果,而相对b波振幅恢复率显著高于timolol治疗组,并且显著减少了RGC的丢失率,明显保护了视网膜的组织形态结构.结论alphagan具有明显的降眼压和神经保护双重作用。" @default.
- W3032827813 created "2020-06-05" @default.
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- W3032827813 date "2004-04-10" @default.
- W3032827813 modified "2023-09-25" @default.
- W3032827813 title "Alphagan与Timolol治疗青光眼的实验研究" @default.
- W3032827813 doi "https://doi.org/10.3760/cma.j.issn.1006-4443.2004.04.025" @default.
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