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- W3032836335 abstract "ObjectiveTo explore the clinical features and prognosis of different PML-RARα fusion gene isoforms in acute promyelocytic leukemia (APL).MethodsThe clinical data of 78 patients initially diagnosed with APL in Fujian Medical University Union Hospital from February 2013 to July 2016 were collected. The clinical features and prognosis of different PML-RARα fusion gene isoforms were analyzed.ResultsThere were 32 females (41%) and 46 males (59%) in 78 patients, with a median age of 40 years old (13-68 years old). The most common PML-RARα fusion gene was L type (48.7%, 38/78), followed by S type (46.2%, 36/78) and V type (5.1%, 4/78). The patients with white blood cell count more than 10×109/L (high-risk) occurred mostly in S type (61.1%, 22/36), compared with V type and L type, and there were statistically different (χ 2 = 7.683, P 0.05). The most common occurrence of retinoic acid syndrome (RAS) during treatment was S type (21/36), while rare for L type and V type (χ 2 = 7.633, P 0.05).ConclusionsThe clinical characteristics of different PML-RARα fusion gene isoforms are different, including most-common L type, more-common V type and S type in high risk groups; complicated RAS is commonly found in S type during the treatment. And different isoforms have no effect on the CR and DFS rate.Key words: Leukemia, promyelocytic, acute; Gene fusion; PML-RARα; Isoform" @default.
- W3032836335 created "2020-06-05" @default.
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- W3032836335 date "2019-04-25" @default.
- W3032836335 modified "2023-09-24" @default.
- W3032836335 title "Clinical features of different isoforms of PML-RARα fusion gene in patients with acute promyelocytic leukemia" @default.
- W3032836335 doi "https://doi.org/10.3760/cma.j.issn.1009-9921.2019.04.003" @default.
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