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- W3032851344 abstract "Mammalian target of rapamycin (mTOR) is an important convergence point in many signal pathways,such as cell growth and reproduction,cell cycle regulation,biosynthesis,cell migration.It plays an important role in the occurrence and development of tumor and lung cancer,particularly in the treatment and prognosis.The phosphorylated mTOR controls mRNA translation of specific subgroups by regulating 4EBP and P70S6K downstream pathways,and then affects the biosynthesis.In the non-small cell lung cancer,mTOR can accelerate cell cycle G1-S phase transition,promote cell proliferation.The inhibitors of mTOR signal pathway like Rapamycin,Sirolimus,and Everolimus seem to be reasonable in the treatment of lung cancer.Key words: Non-small cell lung cancer; Mammal target of rapamycin; Phosphatidylinositol 3-kinase" @default.
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- W3032851344 date "2010-09-20" @default.
- W3032851344 modified "2023-09-23" @default.
- W3032851344 title "Relation of mTOR signal pathway and related drugs with non-small cell lung cancer" @default.
- W3032851344 doi "https://doi.org/10.3760/cma.j.issn.1673-436x.2010.018.006" @default.
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