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- W3032860043 abstract "Objective To investigate the expression of cyclooxygenase-2 (COX-2) and E-cadherin( Ecad) in meningioma and the clinical significance. Methods The expressions of Ki-67, COX-2 and E-cad were detected in 60 cases of meningioma by immunohistochemistry method, and the expressions of COX-2 mRNA、EcadmRNA were examined by in situ hybridization. Results There was significant correlation between over-expression of Ki-67、 COX-2 and decreased expression of E-cad with pathologic grade and invasion ( P ＜ 0. 05 ).There was negative correlation between the expression of COX-2 and E-cad ( P ＜ 0. 05 ). Conclusion Expressions of COX-2 and E-cad were significant correlated to pathologic grade and invasion. They may exert mutual effect and co-regulate the invasive growth of meningiomas. Combined detection of COX-2 and E-cad may help to predict the prognosis of patients.Key words: Meningioma; Cyclooxygenase-2; E-cadherin; Immunohistochemistry; In situ hybridization" @default.
- W3032860043 created "2020-06-05" @default.
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- W3032860043 date "2010-11-25" @default.
- W3032860043 modified "2023-09-23" @default.
- W3032860043 title "Clinical significance and expression of cyclooxygenase-2 and E-cadherin in meningioma" @default.
- W3032860043 doi "https://doi.org/10.3760/cma.j.issn1673-8799.2010.11.02" @default.
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