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- W3032885811 abstract "ObjectiveTo explore the changes in pulmonary surfactant (PS) and to analyze the clinical data of the complex congenital heart disease(CHD) infants who got acute respiratory distress syndrome (ARDS) after surgery and those of the simple CHD infants who recovered smoothly after surgery.MethodsFifteen infants less than 3 months with congenital cardiac defects undergoing cardiovascular surgery and developed ARDS after operation were chosen as ARDS group, other 15 infants without ARDS were chosen as a control group.The data of mean mechanical ventilation time, the intensive care unit treatment time, mortality and the incidence of postoperative complications were collected.And saturated phosphatidylcholine(SatPC), total phospholipids(TPL) and total protein(TP) in sequential airway aspirates and surfactant protein-A (SP-A) in the blood after operation were determined.ResultsThe mean mechanical ventilation time of ARDS group[(6.69±2.35)d] was longer than that of the control group[(0.90±0.84) d](t=8.986, P<0.01), and the mean ICU treatment time of ARDS group[(7.20±3.39) d] was longer than that of the control group[(1.56±0.77) d](t=6.283, P<0.01). ARDS group had a higher rate of mortality(6.67%) and the incidence of postoperative complications(46.67%) than that of the control group(0)(F=10.562 5, 2.227 3, all P<0.05). Plasma SP-A level in ARDS group[(148.18±19.18)mg/L] was higher than that in the control group[(93.06±12.39)mg/L](t=9.349, P<0.01). The SatPC/TPL decreased in ARDS group[(0.602 9±0.045 1)%] compared with that in the control group[(0.819 9±0.074 1)% ](t=-9.689, P<0.01). The SatPC/TP was decreased in ARDS group[(0.085 6±0.069 5) mg/g] compared with that in the control group[(0.485 5±0.039 5) mg/g](t=-19.374, P<0.01).ConclusionsARDS after the surgery of CHD may significantly reduces PS activity in the lungs and its loss into blood.Their recovery process may be longer than that of the simple simple CHD infants with unstable conditions.Key words: Congenital heart disease; Acute respiratory distress syndrome; Pulmonary surfactant associated protein" @default.
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- W3032885811 date "2015-01-05" @default.
- W3032885811 modified "2023-09-26" @default.
- W3032885811 title "Changes in pulmonary surfactant in children with acute respiratory distress syndrome in post operation of complex congenital heart disease and its significance" @default.
- W3032885811 doi "https://doi.org/10.3760/cma.j.issn.2095-428x.2015.01.005" @default.
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