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• W3032915037 abstract "Infertility is an important side effect of treatments used for cancer and other non-malignant conditions in males. This may be due to the loss of spermatogonial stem cells (SSCs) and/or altered functionality of testicular somatic cells (e.g. Sertoli cells, Leydig cells). Whereas sperm cryopreservation is the first-line procedure to preserve fertility in post-pubertal males, this option does not exist for prepubertal boys. For patients unable to produce sperm and at high risk of losing their fertility, testicular tissue freezing is now proposed as an alternative experimental option to safeguard their fertility.With this review, we aim to provide an update on clinical practices and experimental methods, as well as to describe patient management inclusion strategies used to preserve and restore the fertility of prepubertal boys at high risk of fertility loss.Based on the expertise of the participating centres and a literature search of the progress in clinical practices, patient management strategies and experimental methods used to preserve and restore the fertility of prepubertal boys at high risk of fertility loss were identified. In addition, a survey was conducted amongst European and North American centres/networks that have published papers on their testicular tissue banking activity.Since the first publication on murine SSC transplantation in 1994, remarkable progress has been made towards clinical application: cryopreservation protocols for testicular tissue have been developed in animal models and are now offered to patients in clinics as a still experimental procedure. Transplantation methods have been adapted for human testis, and the efficiency and safety of the technique are being evaluated in mouse and primate models. However, important practical, medical and ethical issues must be resolved before fertility restoration can be applied in the clinic.Since the previous survey conducted in 2012, the implementation of testicular tissue cryopreservation as a means to preserve the fertility of prepubertal boys has increased. Data have been collected from 24 co-ordinating centres worldwide, which are actively offering testis tissue cryobanking to safeguard the future fertility of boys. More than 1033 young patients (age range 3 months to 18 years) have already undergone testicular tissue retrieval and storage for fertility preservation.The review does not include the data of all reproductive centres worldwide. Other centres might be offering testicular tissue cryopreservation. Therefore, the numbers might be not representative for the entire field in reproductive medicine and biology worldwide. The key ethical issue regarding fertility preservation in prepubertal boys remains the experimental nature of the intervention.The revised procedures can be implemented by the multi-disciplinary teams offering and/or developing treatment strategies to preserve the fertility of prepubertal boys who have a high risk of fertility loss.The work was funded by ESHRE. None of the authors has a conflict of interest." @default.
• W3032915037 created "2020-06-12" @default.
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• W3032915037 date "2020-01-01" @default.
• W3032915037 modified "2023-10-14" @default.
• W3032915037 title "Fertility preservation in boys: recent developments and new insights †" @default.
• W3032915037 cites W1484971215 @default.
• W3032915037 cites W1529911469 @default.
• W3032915037 cites W1561447687 @default.
• W3032915037 cites W1927672794 @default.
• W3032915037 cites W1955218631 @default.
• W3032915037 cites W1963940266 @default.
• W3032915037 cites W1965603638 @default.
• W3032915037 cites W1968469910 @default.
• W3032915037 cites W1968659768 @default.
• W3032915037 cites W1969312674 @default.
• W3032915037 cites W1970952778 @default.
• W3032915037 cites W1974916331 @default.
• W3032915037 cites W1975090303 @default.
• W3032915037 cites W1975665535 @default.
• W3032915037 cites W1977419321 @default.
• W3032915037 cites W1989860433 @default.
• W3032915037 cites W1991417722 @default.
• W3032915037 cites W1993073478 @default.
• W3032915037 cites W1996306577 @default.
• W3032915037 cites W1999077488 @default.
• W3032915037 cites W2000145425 @default.
• W3032915037 cites W2002842590 @default.
• W3032915037 cites W2008995893 @default.
• W3032915037 cites W2009157448 @default.
• W3032915037 cites W2010533975 @default.
• W3032915037 cites W2011252554 @default.
• W3032915037 cites W2016789158 @default.
• W3032915037 cites W2023425534 @default.
• W3032915037 cites W2026622292 @default.
• W3032915037 cites W2031488951 @default.
• W3032915037 cites W2032480797 @default.
• W3032915037 cites W2038381398 @default.
• W3032915037 cites W2040131438 @default.
• W3032915037 cites W2040618161 @default.
• W3032915037 cites W2041369934 @default.
• W3032915037 cites W2048196191 @default.
• W3032915037 cites W2051833172 @default.
• W3032915037 cites W2054194244 @default.
• W3032915037 cites W2054743870 @default.
• W3032915037 cites W2055083450 @default.
• W3032915037 cites W2055219611 @default.
• W3032915037 cites W2057721938 @default.
• W3032915037 cites W2060108583 @default.
• W3032915037 cites W2062332447 @default.
• W3032915037 cites W2068389839 @default.
• W3032915037 cites W2076636664 @default.
• W3032915037 cites W2077786181 @default.
• W3032915037 cites W2078718582 @default.
• W3032915037 cites W2080742539 @default.
• W3032915037 cites W2081023675 @default.
• W3032915037 cites W2081328950 @default.
• W3032915037 cites W2083645676 @default.
• W3032915037 cites W2086400955 @default.
• W3032915037 cites W2090566410 @default.
• W3032915037 cites W2091307155 @default.
• W3032915037 cites W2096312080 @default.
• W3032915037 cites W2098737213 @default.
• W3032915037 cites W2100499879 @default.
• W3032915037 cites W2100943772 @default.
• W3032915037 cites W2101509732 @default.
• W3032915037 cites W2101671328 @default.
• W3032915037 cites W2103853372 @default.
• W3032915037 cites W2107228324 @default.
• W3032915037 cites W2108000890 @default.
• W3032915037 cites W2111078095 @default.
• W3032915037 cites W2111354766 @default.
• W3032915037 cites W2112285984 @default.
• W3032915037 cites W2113046785 @default.
• W3032915037 cites W2116819794 @default.
• W3032915037 cites W2117189099 @default.
• W3032915037 cites W2117989822 @default.

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