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- W3032917085 endingPage "975" @default.
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- W3032917085 abstract "Introduction Toxigenic Clostridium difficile (C. difficile) is the main cause of antibiotic-associated diarrhea and can induce pseudomembranous colitis and infrequent toxic megacolon, which are potentially fatal. The standard antibiotic therapy for C. difficile infection (CDI) is limited by antibiotics’ broad spectrum and further disruptive effects on indigenous microbiota. Probiotics may offer a prospective and alternative strategy for the prevention and treatment of CDI.Areas covered In this article, the mechanisms implying the probiotic effect against C. difficile and the safety profile highlighting the patient groups with inappropriate application of probiotics were reviewed from 2015 to 2020.Expert opinion Although many strains with ability against C. difficile have been reported, the usage of probiotics for CDI prevention and/or treatment is scarce since the number of clinical trials is not sufficient to prove probiotics’ efficacy and safety in CDI treatment, especially for premature infant and immunocompromised patient. Especially, there are few well-defined clinical studies supporting safety of probiotics for CDI. A few strains from Lactobacillus and Saccharomyces genus have been studied more extensively than other probiotic strains through clinical trials for CDI. Thus, more clinical intervention studies regarding the benefit and the comprehensive safety assessments of probiotics for CDI are needed." @default.
- W3032917085 created "2020-06-12" @default.
- W3032917085 creator A5012610482 @default.
- W3032917085 creator A5027004608 @default.
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- W3032917085 creator A5039710655 @default.
- W3032917085 creator A5052223213 @default.
- W3032917085 creator A5086747332 @default.
- W3032917085 date "2020-06-16" @default.
- W3032917085 modified "2023-09-26" @default.
- W3032917085 title "The mechanisms and safety of probiotics against toxigenic <i>clostridium difficile</i>" @default.
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