Matches in SemOpenAlex for { <https://semopenalex.org/work/W3032933262> ?p ?o ?g. }
- W3032933262 endingPage "875" @default.
- W3032933262 startingPage "864" @default.
- W3032933262 abstract "Therapeutic drugs for Alzheimer's disease have been extensively studied due to its recurrence and abundance among neurodegenerative diseases. It is thought that the accumulation of amyloid precursor protein (APP) products, a consequence of an up-regulation of the β-site APP-cleaving enzyme 1 (BACE1), is the main triggering mechanism during the early stages of the disease. This study aims to explore the ability of a multifunctional conjugate based on magnetite nanoparticles for the cellular delivery of siRNA against the expression of the BACE1 gene. We immobilized the siRNA strand on PEGylated magnetite nanoparticles and investigated the effects on biocompatibility and efficacy of the conjugation. Similarly, we co-immobilized the translocating protein OmpA on PEGylated nanoparticles to enhance cellular uptake and endosomal escape. BACE1 suppression was statistically significant in HFF-1 cells, without any presence of a cytotoxic effect. The delivery of the nanoconjugate was achieved through endocytosis pathways, where endosome formation was likely escaped due to the proton-sponge effect characteristic of PEGylated nanoparticles or mainly by direct translocation in the case of OmpA/PEGylated nanoparticles." @default.
- W3032933262 created "2020-06-12" @default.
- W3032933262 creator A5005252603 @default.
- W3032933262 creator A5008352104 @default.
- W3032933262 creator A5008382983 @default.
- W3032933262 creator A5014023492 @default.
- W3032933262 creator A5023448506 @default.
- W3032933262 creator A5039861097 @default.
- W3032933262 creator A5056807230 @default.
- W3032933262 creator A5061819185 @default.
- W3032933262 creator A5077873874 @default.
- W3032933262 date "2020-01-01" @default.
- W3032933262 modified "2023-10-14" @default.
- W3032933262 title "Multifunctional magnetite nanoparticles to enable delivery of siRNA for the potential treatment of Alzheimer’s" @default.
- W3032933262 cites W1488696728 @default.
- W3032933262 cites W1596984737 @default.
- W3032933262 cites W1647075334 @default.
- W3032933262 cites W1974605548 @default.
- W3032933262 cites W1980560815 @default.
- W3032933262 cites W1993426606 @default.
- W3032933262 cites W2005497577 @default.
- W3032933262 cites W2006323020 @default.
- W3032933262 cites W2011303819 @default.
- W3032933262 cites W2047731010 @default.
- W3032933262 cites W2047983204 @default.
- W3032933262 cites W2051814551 @default.
- W3032933262 cites W2066234893 @default.
- W3032933262 cites W2073608260 @default.
- W3032933262 cites W2074210309 @default.
- W3032933262 cites W2081458774 @default.
- W3032933262 cites W2087914948 @default.
- W3032933262 cites W2111255810 @default.
- W3032933262 cites W2120738018 @default.
- W3032933262 cites W2120820989 @default.
- W3032933262 cites W2124627567 @default.
- W3032933262 cites W2126231259 @default.
- W3032933262 cites W2160678872 @default.
- W3032933262 cites W2314130278 @default.
- W3032933262 cites W2324144545 @default.
- W3032933262 cites W2344949123 @default.
- W3032933262 cites W2415660587 @default.
- W3032933262 cites W2587114059 @default.
- W3032933262 cites W2591225719 @default.
- W3032933262 cites W2593962402 @default.
- W3032933262 cites W2607241233 @default.
- W3032933262 cites W2736509743 @default.
- W3032933262 cites W2811485451 @default.
- W3032933262 cites W2886331943 @default.
- W3032933262 cites W2982128103 @default.
- W3032933262 cites W2988754526 @default.
- W3032933262 cites W380069984 @default.
- W3032933262 cites W4210975612 @default.
- W3032933262 cites W4239628118 @default.
- W3032933262 cites W640316070 @default.
- W3032933262 doi "https://doi.org/10.1080/10717544.2020.1775724" @default.
- W3032933262 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8216449" @default.
- W3032933262 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32515999" @default.
- W3032933262 hasPublicationYear "2020" @default.
- W3032933262 type Work @default.
- W3032933262 sameAs 3032933262 @default.
- W3032933262 citedByCount "22" @default.
- W3032933262 countsByYear W30329332622020 @default.
- W3032933262 countsByYear W30329332622021 @default.
- W3032933262 countsByYear W30329332622022 @default.
- W3032933262 countsByYear W30329332622023 @default.
- W3032933262 crossrefType "journal-article" @default.
- W3032933262 hasAuthorship W3032933262A5005252603 @default.
- W3032933262 hasAuthorship W3032933262A5008352104 @default.
- W3032933262 hasAuthorship W3032933262A5008382983 @default.
- W3032933262 hasAuthorship W3032933262A5014023492 @default.
- W3032933262 hasAuthorship W3032933262A5023448506 @default.
- W3032933262 hasAuthorship W3032933262A5039861097 @default.
- W3032933262 hasAuthorship W3032933262A5056807230 @default.
- W3032933262 hasAuthorship W3032933262A5061819185 @default.
- W3032933262 hasAuthorship W3032933262A5077873874 @default.
- W3032933262 hasBestOaLocation W30329332621 @default.
- W3032933262 hasConcept C155672457 @default.
- W3032933262 hasConcept C171250308 @default.
- W3032933262 hasConcept C191897082 @default.
- W3032933262 hasConcept C192562407 @default.
- W3032933262 hasConcept C2777781897 @default.
- W3032933262 hasConcept C2910607562 @default.
- W3032933262 hasConcept C87023908 @default.
- W3032933262 hasConceptScore W3032933262C155672457 @default.
- W3032933262 hasConceptScore W3032933262C171250308 @default.
- W3032933262 hasConceptScore W3032933262C191897082 @default.
- W3032933262 hasConceptScore W3032933262C192562407 @default.
- W3032933262 hasConceptScore W3032933262C2777781897 @default.
- W3032933262 hasConceptScore W3032933262C2910607562 @default.
- W3032933262 hasConceptScore W3032933262C87023908 @default.
- W3032933262 hasIssue "1" @default.
- W3032933262 hasLocation W30329332621 @default.
- W3032933262 hasLocation W30329332622 @default.
- W3032933262 hasLocation W30329332623 @default.
- W3032933262 hasOpenAccess W3032933262 @default.
- W3032933262 hasPrimaryLocation W30329332621 @default.
- W3032933262 hasRelatedWork W1543538561 @default.
- W3032933262 hasRelatedWork W1598461806 @default.