FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3032948654> ?p ?o ?g. }

• W3032948654 endingPage "127308" @default.
• W3032948654 startingPage "127308" @default.
• W3032948654 abstract "Evidence indicates that hepatitis C virus (HCV) utilizes cellular cyclophilin proteins in its replication, and cyclophilin inhibitors represent a new class of anti-HCV agents. We have established an efficient synthetic methodology to generate FR901459 derivatives via N, O-acyl migration reaction while avoiding total synthesis. Through a detailed structure–activity relationship study, we improved anti-HCV activity while decreasing immunosuppressive activity. Additionally, we discovered the importance of substitution at the 3 position for not only improving anti-HCV activity but also pharmacokinetic profile. Finally, by striking an appropriate balance between potency, solubility, and permeability, we discovered ASP5286 (13) as a potential clinical candidate for anti-HCV therapy." @default.
• W3032948654 created "2020-06-12" @default.
• W3032948654 creator A5012919892 @default.
• W3032948654 creator A5021825332 @default.
• W3032948654 creator A5030216704 @default.
• W3032948654 creator A5046433978 @default.
• W3032948654 creator A5058895882 @default.
• W3032948654 creator A5065736006 @default.
• W3032948654 creator A5068868114 @default.
• W3032948654 date "2020-08-01" @default.
• W3032948654 modified "2023-10-16" @default.
• W3032948654 title "Discovery of ASP5286: A novel non-immunosuppressive cyclophilin inhibitor for the treatment of HCV" @default.
• W3032948654 cites W1969751158 @default.
• W3032948654 cites W1978182746 @default.
• W3032948654 cites W1987775509 @default.
• W3032948654 cites W1993496957 @default.
• W3032948654 cites W1995374823 @default.
• W3032948654 cites W1999338768 @default.
• W3032948654 cites W2006124613 @default.
• W3032948654 cites W2010852698 @default.
• W3032948654 cites W2015591423 @default.
• W3032948654 cites W2015868830 @default.
• W3032948654 cites W2018339055 @default.
• W3032948654 cites W2023406003 @default.
• W3032948654 cites W2025215815 @default.
• W3032948654 cites W2033480003 @default.
• W3032948654 cites W2051841808 @default.
• W3032948654 cites W2054134813 @default.
• W3032948654 cites W2062153657 @default.
• W3032948654 cites W2070347865 @default.
• W3032948654 cites W2072949849 @default.
• W3032948654 cites W2079146411 @default.
• W3032948654 cites W2089924322 @default.
• W3032948654 cites W2105054339 @default.
• W3032948654 cites W2106820168 @default.
• W3032948654 cites W2129054887 @default.
• W3032948654 cites W2152561379 @default.
• W3032948654 cites W2159348270 @default.
• W3032948654 cites W2163248409 @default.
• W3032948654 cites W2318156787 @default.
• W3032948654 cites W2324272627 @default.
• W3032948654 cites W2336799715 @default.
• W3032948654 cites W2558867729 @default.
• W3032948654 cites W4235013560 @default.
• W3032948654 cites W4249074344 @default.
• W3032948654 cites W4255041681 @default.
• W3032948654 cites W45088497 @default.
• W3032948654 doi "https://doi.org/10.1016/j.bmcl.2020.127308" @default.
• W3032948654 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32631528" @default.
• W3032948654 hasPublicationYear "2020" @default.
• W3032948654 type Work @default.
• W3032948654 sameAs 3032948654 @default.
• W3032948654 citedByCount "2" @default.
• W3032948654 countsByYear W30329486542021 @default.
• W3032948654 countsByYear W30329486542022 @default.
• W3032948654 crossrefType "journal-article" @default.
• W3032948654 hasAuthorship W3032948654A5012919892 @default.
• W3032948654 hasAuthorship W3032948654A5021825332 @default.
• W3032948654 hasAuthorship W3032948654A5030216704 @default.
• W3032948654 hasAuthorship W3032948654A5046433978 @default.
• W3032948654 hasAuthorship W3032948654A5058895882 @default.
• W3032948654 hasAuthorship W3032948654A5065736006 @default.
• W3032948654 hasAuthorship W3032948654A5068868114 @default.
• W3032948654 hasConcept C104317684 @default.
• W3032948654 hasConcept C140704245 @default.
• W3032948654 hasConcept C153911025 @default.
• W3032948654 hasConcept C159047783 @default.
• W3032948654 hasConcept C185592680 @default.
• W3032948654 hasConcept C202751555 @default.
• W3032948654 hasConcept C2522874641 @default.
• W3032948654 hasConcept C2776326521 @default.
• W3032948654 hasConcept C2776408679 @default.
• W3032948654 hasConcept C2777510210 @default.
• W3032948654 hasConcept C2780778672 @default.
• W3032948654 hasConcept C2781463415 @default.
• W3032948654 hasConcept C2909439513 @default.
• W3032948654 hasConcept C3019038264 @default.
• W3032948654 hasConcept C55493867 @default.
• W3032948654 hasConcept C57992300 @default.
• W3032948654 hasConcept C74187038 @default.
• W3032948654 hasConcept C86803240 @default.
• W3032948654 hasConcept C98274493 @default.
• W3032948654 hasConceptScore W3032948654C104317684 @default.
• W3032948654 hasConceptScore W3032948654C140704245 @default.
• W3032948654 hasConceptScore W3032948654C153911025 @default.
• W3032948654 hasConceptScore W3032948654C159047783 @default.
• W3032948654 hasConceptScore W3032948654C185592680 @default.
• W3032948654 hasConceptScore W3032948654C202751555 @default.
• W3032948654 hasConceptScore W3032948654C2522874641 @default.
• W3032948654 hasConceptScore W3032948654C2776326521 @default.
• W3032948654 hasConceptScore W3032948654C2776408679 @default.
• W3032948654 hasConceptScore W3032948654C2777510210 @default.
• W3032948654 hasConceptScore W3032948654C2780778672 @default.
• W3032948654 hasConceptScore W3032948654C2781463415 @default.
• W3032948654 hasConceptScore W3032948654C2909439513 @default.
• W3032948654 hasConceptScore W3032948654C3019038264 @default.
• W3032948654 hasConceptScore W3032948654C55493867 @default.
• W3032948654 hasConceptScore W3032948654C57992300 @default.

• next