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- W3033010906 endingPage "107743" @default.
- W3033010906 startingPage "107743" @default.
- W3033010906 abstract "The organization of spatial information, including pattern completion and pattern separation processes, relies on the hippocampal circuits, yet the molecular and cellular mechanisms underlying these two processes are elusive. Here, we find that loss of Vangl2, a core PCP gene, results in opposite effects on pattern completion and pattern separation processes. Mechanistically, we show that Vangl2 loss maintains young postmitotic granule cells in an immature state, providing increased cellular input for pattern separation. The genetic ablation of Vangl2 disrupts granule cell morpho-functional maturation and further prevents CaMKII and GluA1 phosphorylation, disrupting the stabilization of AMPA receptors. As a functional consequence, LTP at lateral perforant path-GC synapses is impaired, leading to defects in pattern completion behavior. In conclusion, we show that Vangl2 exerts a bimodal regulation on young and mature GCs, and its disruption leads to an imbalance in hippocampus-dependent pattern completion and separation processes." @default.
- W3033010906 created "2020-06-12" @default.
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- W3033010906 date "2020-06-01" @default.
- W3033010906 modified "2023-10-16" @default.
- W3033010906 title "Vangl2 in the Dentate Network Modulates Pattern Separation and Pattern Completion" @default.
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- W3033010906 doi "https://doi.org/10.1016/j.celrep.2020.107743" @default.
- W3033010906 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7296350" @default.
- W3033010906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32521268" @default.
- W3033010906 hasPublicationYear "2020" @default.
- W3033010906 type Work @default.