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- W3033070050 endingPage "1384" @default.
- W3033070050 startingPage "1384" @default.
- W3033070050 abstract "The mitochondria are key organelles regulating vital processes in the eukaryote cell. A decline in mitochondrial function is one of the hallmarks of aging. Growth hormone (GH) and the insulin-like growth factor-1 (IGF-1) are somatotropic hormones that regulate cellular homeostasis and play significant roles in cell differentiation, function, and survival. In mammals, these hormones peak during puberty and decline gradually during adulthood and aging. Here, we review the evidence that GH and IGF-1 regulate mitochondrial mass and function and contribute to specific processes of cellular aging. Specifically, we discuss the contribution of GH and IGF-1 to mitochondrial biogenesis, respiration and ATP production, oxidative stress, senescence, and apoptosis. Particular emphasis was placed on how these pathways intersect during aging." @default.
- W3033070050 created "2020-06-12" @default.
- W3033070050 creator A5003904670 @default.
- W3033070050 creator A5007898120 @default.
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- W3033070050 creator A5033881645 @default.
- W3033070050 creator A5044135085 @default.
- W3033070050 creator A5065919583 @default.
- W3033070050 date "2020-06-02" @default.
- W3033070050 modified "2023-10-04" @default.
- W3033070050 title "Effects of GH/IGF on the Aging Mitochondria" @default.
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