Matches in SemOpenAlex for { <https://semopenalex.org/work/W3033093553> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W3033093553 endingPage "785" @default.
- W3033093553 startingPage "782" @default.
- W3033093553 abstract "Abstract The pandemic of respiratory illness caused by a novel coronavirus (SARS‐nCoV‐2) is a global health crisis. Despite numerous preliminary results, there is as yet no treatment of proven efficacy for this condition. In this context, the pharmacological properties of lithium, better known as a treatment for mood disorders, merit closer examination. Lithium has shown in vitro efficacy at inhibiting the replication of coronaviruses responsible for gastrointestinal and respiratory diseases in animals. It has immunomodulatory properties that may be of additional benefit in moderating the host inflammatory response to the novel coronavirus (SARS‐CoV‐2). Furthermore, there is evidence that lithium may exert a protective action against upper respiratory infections and influenza‐like illnesses in patients taking it for other indications. These promising reports must be balanced against the narrow therapeutic index and high risk of toxicity associated with lithium therapy, its documented interactions with several commonly used drugs, and the absence of evidence of its efficacy against coronaviruses responsible for human disease. Nevertheless, naturalistic studies of the risk of COVID‐19 in patients already receiving lithium could provide indirect evidence of its efficacy, and understanding the putative antiviral and immune‐regulatory mechanisms of lithium in models of SARS‐CoV‐2 infection may provide leads for the development of safer and more effective treatments with a specific action against COVID‐19." @default.
- W3033093553 created "2020-06-12" @default.
- W3033093553 creator A5008819309 @default.
- W3033093553 date "2020-06-10" @default.
- W3033093553 modified "2023-10-18" @default.
- W3033093553 title "Lithium as a candidate treatment for <scp>COVID</scp>‐19: Promises and pitfalls" @default.
- W3033093553 cites W1574240350 @default.
- W3033093553 cites W1976343894 @default.
- W3033093553 cites W1980667027 @default.
- W3033093553 cites W1988010703 @default.
- W3033093553 cites W1996743976 @default.
- W3033093553 cites W2022603716 @default.
- W3033093553 cites W2030103036 @default.
- W3033093553 cites W2047816071 @default.
- W3033093553 cites W2051110479 @default.
- W3033093553 cites W2066786363 @default.
- W3033093553 cites W2078592527 @default.
- W3033093553 cites W2089774757 @default.
- W3033093553 cites W2110363413 @default.
- W3033093553 cites W2290542171 @default.
- W3033093553 cites W2333485767 @default.
- W3033093553 cites W2409050272 @default.
- W3033093553 cites W2618201060 @default.
- W3033093553 cites W2792680312 @default.
- W3033093553 cites W3009912996 @default.
- W3033093553 cites W3011802905 @default.
- W3033093553 cites W3012621030 @default.
- W3033093553 cites W3014644244 @default.
- W3033093553 cites W3016538246 @default.
- W3033093553 cites W3019598142 @default.
- W3033093553 cites W3020703902 @default.
- W3033093553 cites W3020892262 @default.
- W3033093553 cites W3023609353 @default.
- W3033093553 doi "https://doi.org/10.1002/ddr.21701" @default.
- W3033093553 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7307055" @default.
- W3033093553 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32524646" @default.
- W3033093553 hasPublicationYear "2020" @default.
- W3033093553 type Work @default.
- W3033093553 sameAs 3033093553 @default.
- W3033093553 citedByCount "16" @default.
- W3033093553 countsByYear W30330935532020 @default.
- W3033093553 countsByYear W30330935532021 @default.
- W3033093553 countsByYear W30330935532022 @default.
- W3033093553 crossrefType "journal-article" @default.
- W3033093553 hasAuthorship W3033093553A5008819309 @default.
- W3033093553 hasBestOaLocation W30330935531 @default.
- W3033093553 hasConcept C118552586 @default.
- W3033093553 hasConcept C126322002 @default.
- W3033093553 hasConcept C151730666 @default.
- W3033093553 hasConcept C177713679 @default.
- W3033093553 hasConcept C203014093 @default.
- W3033093553 hasConcept C2777648638 @default.
- W3033093553 hasConcept C2778541603 @default.
- W3033093553 hasConcept C2779134260 @default.
- W3033093553 hasConcept C2779343474 @default.
- W3033093553 hasConcept C3008058167 @default.
- W3033093553 hasConcept C524204448 @default.
- W3033093553 hasConcept C71924100 @default.
- W3033093553 hasConcept C86803240 @default.
- W3033093553 hasConcept C89623803 @default.
- W3033093553 hasConcept C98274493 @default.
- W3033093553 hasConceptScore W3033093553C118552586 @default.
- W3033093553 hasConceptScore W3033093553C126322002 @default.
- W3033093553 hasConceptScore W3033093553C151730666 @default.
- W3033093553 hasConceptScore W3033093553C177713679 @default.
- W3033093553 hasConceptScore W3033093553C203014093 @default.
- W3033093553 hasConceptScore W3033093553C2777648638 @default.
- W3033093553 hasConceptScore W3033093553C2778541603 @default.
- W3033093553 hasConceptScore W3033093553C2779134260 @default.
- W3033093553 hasConceptScore W3033093553C2779343474 @default.
- W3033093553 hasConceptScore W3033093553C3008058167 @default.
- W3033093553 hasConceptScore W3033093553C524204448 @default.
- W3033093553 hasConceptScore W3033093553C71924100 @default.
- W3033093553 hasConceptScore W3033093553C86803240 @default.
- W3033093553 hasConceptScore W3033093553C89623803 @default.
- W3033093553 hasConceptScore W3033093553C98274493 @default.
- W3033093553 hasIssue "7" @default.
- W3033093553 hasLocation W30330935531 @default.
- W3033093553 hasLocation W30330935532 @default.
- W3033093553 hasLocation W30330935533 @default.
- W3033093553 hasOpenAccess W3033093553 @default.
- W3033093553 hasPrimaryLocation W30330935531 @default.
- W3033093553 hasRelatedWork W3016034056 @default.
- W3033093553 hasRelatedWork W3028088776 @default.
- W3033093553 hasRelatedWork W3042475662 @default.
- W3033093553 hasRelatedWork W3045220971 @default.
- W3033093553 hasRelatedWork W3048636488 @default.
- W3033093553 hasRelatedWork W3166028832 @default.
- W3033093553 hasRelatedWork W3191018337 @default.
- W3033093553 hasRelatedWork W3199480183 @default.
- W3033093553 hasRelatedWork W3201614372 @default.
- W3033093553 hasRelatedWork W4205954245 @default.
- W3033093553 hasVolume "81" @default.
- W3033093553 isParatext "false" @default.
- W3033093553 isRetracted "false" @default.
- W3033093553 magId "3033093553" @default.
- W3033093553 workType "article" @default.