Matches in SemOpenAlex for { <https://semopenalex.org/work/W3033093721> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W3033093721 endingPage "127304" @default.
- W3033093721 startingPage "127304" @default.
- W3033093721 abstract "A new series of 1,2,3-triazole tethered chalcone acetamide derivatives (7a-c & 8a-r) have been synthesized in excellent yields and their structures were determined by analytical and spectral (FT-IR, 1H NMR, 13C NMR & HRMS) studies. The newly synthesized derivatives were evaluated for their cytotoxic activity against four human cancer cell lines, such as HeLa (Human cervical cancer), A549 (Human alveolar adenocarcinoma), MCF-7 (Human breast adenocarcinoma) and SKNSH (Human brain cancer). Among them, compound 7c exhibited good anti-proliferation activity with HeLa (IC50 7.41 + 0.8 μM), SKNSH (IC50 8.68 + 1.1 μM), MCF-7 (IC50 9.76 + 1.3 μM) and MDA-MB-231, while compounds 7a and 7b showed promising anti-proliferation against above four human cancer cell lines with IC50 7.95–11.62 μM, respectively, compared with the standard drug Doxorubicin. We explored the probable key active site and binding mode interactions in HDAC8 (PDB ID:3SFH) and EHMT2 (PDB ID:3K5K) proteins. The docking results are complementary to the experimental observations." @default.
- W3033093721 created "2020-06-12" @default.
- W3033093721 creator A5015355243 @default.
- W3033093721 creator A5016862201 @default.
- W3033093721 creator A5029561889 @default.
- W3033093721 creator A5038321309 @default.
- W3033093721 creator A5073570615 @default.
- W3033093721 date "2020-08-01" @default.
- W3033093721 modified "2023-10-16" @default.
- W3033093721 title "Synthesis and anti-proliferative activity of a novel 1,2,3-triazole tethered chalcone acetamide derivatives" @default.
- W3033093721 cites W1964505084 @default.
- W3033093721 cites W1973825719 @default.
- W3033093721 cites W1981870462 @default.
- W3033093721 cites W2008125363 @default.
- W3033093721 cites W2015879712 @default.
- W3033093721 cites W2025189079 @default.
- W3033093721 cites W2030579366 @default.
- W3033093721 cites W2048394663 @default.
- W3033093721 cites W2054075987 @default.
- W3033093721 cites W2063820454 @default.
- W3033093721 cites W2076393055 @default.
- W3033093721 cites W2133857972 @default.
- W3033093721 cites W2500130455 @default.
- W3033093721 cites W2502358765 @default.
- W3033093721 cites W2538760465 @default.
- W3033093721 cites W2767162333 @default.
- W3033093721 cites W2793928941 @default.
- W3033093721 doi "https://doi.org/10.1016/j.bmcl.2020.127304" @default.
- W3033093721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32631524" @default.
- W3033093721 hasPublicationYear "2020" @default.
- W3033093721 type Work @default.
- W3033093721 sameAs 3033093721 @default.
- W3033093721 citedByCount "22" @default.
- W3033093721 countsByYear W30330937212020 @default.
- W3033093721 countsByYear W30330937212021 @default.
- W3033093721 countsByYear W30330937212022 @default.
- W3033093721 countsByYear W30330937212023 @default.
- W3033093721 crossrefType "journal-article" @default.
- W3033093721 hasAuthorship W3033093721A5015355243 @default.
- W3033093721 hasAuthorship W3033093721A5016862201 @default.
- W3033093721 hasAuthorship W3033093721A5029561889 @default.
- W3033093721 hasAuthorship W3033093721A5038321309 @default.
- W3033093721 hasAuthorship W3033093721A5073570615 @default.
- W3033093721 hasConcept C159110408 @default.
- W3033093721 hasConcept C178790620 @default.
- W3033093721 hasConcept C185592680 @default.
- W3033093721 hasConcept C202751555 @default.
- W3033093721 hasConcept C2776730177 @default.
- W3033093721 hasConcept C2777366897 @default.
- W3033093721 hasConcept C2777752497 @default.
- W3033093721 hasConcept C2780764945 @default.
- W3033093721 hasConcept C41685203 @default.
- W3033093721 hasConcept C55493867 @default.
- W3033093721 hasConcept C62112901 @default.
- W3033093721 hasConcept C65556437 @default.
- W3033093721 hasConcept C71240020 @default.
- W3033093721 hasConcept C71924100 @default.
- W3033093721 hasConceptScore W3033093721C159110408 @default.
- W3033093721 hasConceptScore W3033093721C178790620 @default.
- W3033093721 hasConceptScore W3033093721C185592680 @default.
- W3033093721 hasConceptScore W3033093721C202751555 @default.
- W3033093721 hasConceptScore W3033093721C2776730177 @default.
- W3033093721 hasConceptScore W3033093721C2777366897 @default.
- W3033093721 hasConceptScore W3033093721C2777752497 @default.
- W3033093721 hasConceptScore W3033093721C2780764945 @default.
- W3033093721 hasConceptScore W3033093721C41685203 @default.
- W3033093721 hasConceptScore W3033093721C55493867 @default.
- W3033093721 hasConceptScore W3033093721C62112901 @default.
- W3033093721 hasConceptScore W3033093721C65556437 @default.
- W3033093721 hasConceptScore W3033093721C71240020 @default.
- W3033093721 hasConceptScore W3033093721C71924100 @default.
- W3033093721 hasFunder F4320320721 @default.
- W3033093721 hasIssue "16" @default.
- W3033093721 hasLocation W30330937211 @default.
- W3033093721 hasOpenAccess W3033093721 @default.
- W3033093721 hasPrimaryLocation W30330937211 @default.
- W3033093721 hasRelatedWork W2013056086 @default.
- W3033093721 hasRelatedWork W2057931667 @default.
- W3033093721 hasRelatedWork W2071649533 @default.
- W3033093721 hasRelatedWork W2218170419 @default.
- W3033093721 hasRelatedWork W2258029851 @default.
- W3033093721 hasRelatedWork W2292936365 @default.
- W3033093721 hasRelatedWork W2801635899 @default.
- W3033093721 hasRelatedWork W2969683195 @default.
- W3033093721 hasRelatedWork W3030596652 @default.
- W3033093721 hasRelatedWork W3084129505 @default.
- W3033093721 hasVolume "30" @default.
- W3033093721 isParatext "false" @default.
- W3033093721 isRetracted "false" @default.
- W3033093721 magId "3033093721" @default.
- W3033093721 workType "article" @default.