FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3033112907> ?p ?o ?g. }

• W3033112907 endingPage "647" @default.
• W3033112907 startingPage "640" @default.
• W3033112907 abstract "Primary CNS lymphoma (PCNSL) is an aggressive brain tumor that represents a significant challenge both to elucidate its biological pathogenesis as well as to develop definitive precision medicines with minimal collateral toxicity. We highlight the key issues in diagnosis and treatment and focus on emerging technologies, current options among consolidation strategies, and biological agents. We anticipate that further development of molecular diagnostics and molecular imaging approaches that elucidate minimal residual disease in brain parenchyma, leptomeninges, intraocular compartments and even bone marrow will greatly impact the delivery and timing of cytotoxic and biological therapies. Implementation of these approaches is likely essential to clarify ongoing discrepancies in the interpretation of clinical trial results that currently are based on relatively unrefined definitions of response. While the results of early phase investigations involving ibrutinib and the IMiD agents, lenalidomide, pomalidomide, as well as avadomide, strongly support the hypothesis that the B-cell receptor (BCR) pathway, involving MYD88 and CD79B and NF-kB activation, is critical to the pathogenesis of PCNSL, much work is needed to elucidate mechanisms of resistance. Similarly, development of strategies to overcome immunosuppressive mechanisms that are upregulated in the tumor microenvironment is a high priority. Finally, ongoing evidence supports the hypothesis that the blood-brain barrier represents a significant impediment to efficient brain tumor penetration of novel therapeutic agents and innovative strategies of drug delivery remain essential to further improve outcomes." @default.
• W3033112907 created "2020-06-12" @default.
• W3033112907 creator A5012380813 @default.
• W3033112907 creator A5051911084 @default.
• W3033112907 creator A5060120275 @default.
• W3033112907 date "2020-07-03" @default.
• W3033112907 modified "2023-10-13" @default.
• W3033112907 title "On point in primary<scp>CNS</scp>lymphoma" @default.
• W3033112907 cites W1860711823 @default.
• W3033112907 cites W1959628099 @default.
• W3033112907 cites W1966424580 @default.
• W3033112907 cites W1975556207 @default.
• W3033112907 cites W1986354050 @default.
• W3033112907 cites W1989857887 @default.
• W3033112907 cites W1994004225 @default.
• W3033112907 cites W2018992636 @default.
• W3033112907 cites W2024292542 @default.
• W3033112907 cites W2050667838 @default.
• W3033112907 cites W2062721282 @default.
• W3033112907 cites W2063632665 @default.
• W3033112907 cites W2076372621 @default.
• W3033112907 cites W2082969877 @default.
• W3033112907 cites W2090012912 @default.
• W3033112907 cites W2094644987 @default.
• W3033112907 cites W2106177078 @default.
• W3033112907 cites W2106336939 @default.
• W3033112907 cites W2106705123 @default.
• W3033112907 cites W2116382435 @default.
• W3033112907 cites W2119331159 @default.
• W3033112907 cites W2126778627 @default.
• W3033112907 cites W2132436881 @default.
• W3033112907 cites W2140561532 @default.
• W3033112907 cites W2142604595 @default.
• W3033112907 cites W2145420680 @default.
• W3033112907 cites W2145453495 @default.
• W3033112907 cites W2145727048 @default.
• W3033112907 cites W2149603266 @default.
• W3033112907 cites W2150975690 @default.
• W3033112907 cites W2159708587 @default.
• W3033112907 cites W2162506220 @default.
• W3033112907 cites W2169143399 @default.
• W3033112907 cites W2170487277 @default.
• W3033112907 cites W2297585449 @default.
• W3033112907 cites W2314481096 @default.
• W3033112907 cites W2461875345 @default.
• W3033112907 cites W2469237805 @default.
• W3033112907 cites W2564906907 @default.
• W3033112907 cites W2600581432 @default.
• W3033112907 cites W2617968907 @default.
• W3033112907 cites W2625473279 @default.
• W3033112907 cites W2738576011 @default.
• W3033112907 cites W2746068181 @default.
• W3033112907 cites W2766491362 @default.
• W3033112907 cites W2767563585 @default.
• W3033112907 cites W2780889590 @default.
• W3033112907 cites W2789508123 @default.
• W3033112907 cites W2795007341 @default.
• W3033112907 cites W2843787264 @default.
• W3033112907 cites W2884510458 @default.
• W3033112907 cites W2894051390 @default.
• W3033112907 cites W2903669497 @default.
• W3033112907 cites W2912416355 @default.
• W3033112907 cites W2914256533 @default.
• W3033112907 cites W2917478934 @default.
• W3033112907 cites W2943123920 @default.
• W3033112907 cites W2968968970 @default.
• W3033112907 cites W3001407138 @default.
• W3033112907 cites W72650883 @default.
• W3033112907 cites W94592798 @default.
• W3033112907 doi "https://doi.org/10.1002/hon.2761" @default.
• W3033112907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32510610" @default.
• W3033112907 hasPublicationYear "2020" @default.
• W3033112907 type Work @default.
• W3033112907 sameAs 3033112907 @default.
• W3033112907 citedByCount "10" @default.
• W3033112907 countsByYear W30331129072021 @default.
• W3033112907 countsByYear W30331129072022 @default.
• W3033112907 countsByYear W30331129072023 @default.
• W3033112907 crossrefType "journal-article" @default.
• W3033112907 hasAuthorship W3033112907A5012380813 @default.
• W3033112907 hasAuthorship W3033112907A5051911084 @default.
• W3033112907 hasAuthorship W3033112907A5060120275 @default.
• W3033112907 hasBestOaLocation W30331129072 @default.
• W3033112907 hasConcept C142724271 @default.
• W3033112907 hasConcept C203014093 @default.
• W3033112907 hasConcept C2776063141 @default.
• W3033112907 hasConcept C2776107976 @default.
• W3033112907 hasConcept C2776364478 @default.
• W3033112907 hasConcept C2777938653 @default.
• W3033112907 hasConcept C2778461978 @default.
• W3033112907 hasConcept C2778524551 @default.
• W3033112907 hasConcept C2779338263 @default.
• W3033112907 hasConcept C2779878957 @default.
• W3033112907 hasConcept C2780035454 @default.
• W3033112907 hasConcept C502942594 @default.
• W3033112907 hasConcept C535046627 @default.
• W3033112907 hasConcept C60644358 @default.
• W3033112907 hasConcept C64903051 @default.

• next