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• W3033124493 abstract "Since data on metachronous risk for patients with index proximal 5-9 mm hyperplastic polyps (HPs) are limited, the clinical significance of these polyps is unclear. Conversely, published data suggest that other serrated polyps such as sessile serrated polyps (SSPs), traditional serrated adenomas (TSAs) and large (≥ 1 cm) hyperplastic polyps (HPs) are high-risk lesions requiring close surveillance. We used data from the New Hampshire Colonoscopy Registry (NHCR) to examine the risk of metachronous large (≥ 1 cm) SPs and advanced adenomas in patients with 5-9 mm proximal HPs. We included adults with at least one polyp resected at index colonoscopy and a surveillance exam at least 1 year after index. Outcomes were risk for metachronous large (≥ 1 cm) SPs and advanced conventional adenomas (AA) (≥ 1 cm, villous elements, HGD or CRC). Individuals were hierarchically stratified by the most significant index SP. The risks for adults with 5-9 mm HPs proximal were compared to the following comparison groups; large (≥ 1 cm) HPs, SSPs or TSA; non-significant HPs (< 1 cm in rectosigmoid or < 5 mm); low risk adenomas (no SPs); and high risk adenomas (AA or ≥ 3 adenomas) (SPs). We present absolute risk as well as adjusted risks of metachronous polyps from a regression model which included age, sex, BMI, smoking, previous polyp history, family history of CRC, year of diagnosis and months to surveillance exam. 8560 NHCR participants were included (44.8% women, average age 59.0 years, SD 9.1). Similar to those with large HPs or SSPs/TSAs at index exam (OR = 4.18; 95% CI: 2.74-6.37), individuals with proximal 5-9 mm HPs had an elevated risk for metachronous large SPs (OR = 2.64 95% CI: 1.41-4.92) as compared to adults with conventional adenomas. Individuals with non-significant HPs did not have an increased risk (OR = 1.16 95% CI: 0.73-1.87). Patients with only index serrated polyps did not have an increased risk for metacachronous advanced adenomas. These data are in Table 1. Our data suggest that similar to adults with large HPs, SSPs or TSAs at index exam, individuals with index 5-9 mm HPs proximal to the sigmoid are at an increased risk for metachronous large SPs. These novel data suggest that close surveillance intervals may be appropriate for patients with 5-9 mm proximal HPs." @default.
• W3033124493 created "2020-06-12" @default.
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• W3033124493 date "2020-06-01" @default.
• W3033124493 modified "2023-09-25" @default.
• W3033124493 title "1184 ARE PROXIMAL 5-9 MM HYPERPLASTIC POLYPS SIGNIFICANT LESIONS? DATA EXAMINING METACHRONOUS RISK OF LARGE (=> 1 CM) SERRATED POLYPS AND ADVANCED CONVENTIONAL ADENOMAS FOR PATIENTS WITH THESE LESIONS IN THE NEW HAMPSHIRE COLONOSCOPY REGISTRY" @default.
• W3033124493 doi "https://doi.org/10.1016/j.gie.2020.03.899" @default.
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