FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3033124927> ?p ?o ?g. }

• W3033124927 endingPage "2279" @default.
• W3033124927 startingPage "2269" @default.
• W3033124927 abstract "Malignant peritoneal mesothelioma is a rare aggressive tumor that arises from the peritoneal lining. While recurrent BAP1 mutations have been identified in a subset of mesotheliomas, molecular characteristics of peritoneal mesotheliomas, including those lacking BAP1 alterations, remain poorly understood. Using targeted next-generation sequencing, we examined the molecular features of 26 diffuse malignant peritoneal mesotheliomas. As part of an exploratory analysis, we analyzed an additional localized peritoneal mesothelioma and one well-differentiated papillary mesothelioma with invasive foci. Genomic characterization identified categories of diffuse malignant peritoneal mesotheliomas: The first group included 18 (69%) tumors with recurrent BAP1 alterations, with eight (31%) having more than one BAP1 alterations, and concomitant alterations in PBRM1 (46%) and SETD2 (35%). All tumors with complete loss of BAP1 expression by immunohistochemistry harbored BAP1 molecular alterations. PBRM1 alterations were significantly enriched in the BAP1-altered cohort. Frequent copy number loss of BAP1, ARID1B, PRDM1, PBRM1, SETD2, NF2, and CDKN2A was noted. The second group included eight (31%) BAP1-wild-type tumors: two with TP53 mutations, one with a TRAF7 activating mutation, one with a SUZ12 inactivating mutation, and three with ALK rearrangements that we previously published. One TP53-mutant biphasic mesothelioma showed evidence of genomic near-haploidization showing loss of heterozygosity of all chromosomes except 5, 7, 16, and 20. The localized peritoneal mesothelioma harbored a nonsense CHEK2 mutation, and the well-differentiated papillary mesothelioma with invasive foci harbored no reportable variants. In conclusion, we described the genetic categories of diffuse malignant peritoneal mesotheliomas, with BAP1-mutant and BAP1-wild-type groups. Our findings implicated DNA repair, epigenetics, and cell cycle regulation in the pathogenesis of peritoneal mesotheliomas, with identification of potential therapeutic targets." @default.
• W3033124927 created "2020-06-12" @default.
• W3033124927 creator A5004265135 @default.
• W3033124927 creator A5038143892 @default.
• W3033124927 creator A5039324896 @default.
• W3033124927 creator A5055130061 @default.
• W3033124927 creator A5086728120 @default.
• W3033124927 creator A5089159833 @default.
• W3033124927 date "2020-11-01" @default.
• W3033124927 modified "2023-10-06" @default.
• W3033124927 title "Molecular characterization of diffuse malignant peritoneal mesothelioma" @default.
• W3033124927 cites W1659637636 @default.
• W3033124927 cites W1923249541 @default.
• W3033124927 cites W1959033078 @default.
• W3033124927 cites W1963534034 @default.
• W3033124927 cites W1968201010 @default.
• W3033124927 cites W1970217079 @default.
• W3033124927 cites W1977307444 @default.
• W3033124927 cites W1982067611 @default.
• W3033124927 cites W1992256507 @default.
• W3033124927 cites W1997207382 @default.
• W3033124927 cites W2004684462 @default.
• W3033124927 cites W2006752813 @default.
• W3033124927 cites W2007265317 @default.
• W3033124927 cites W2007541023 @default.
• W3033124927 cites W2019019261 @default.
• W3033124927 cites W2020349243 @default.
• W3033124927 cites W2024368570 @default.
• W3033124927 cites W2032072849 @default.
• W3033124927 cites W2059978158 @default.
• W3033124927 cites W2070195376 @default.
• W3033124927 cites W2070604281 @default.
• W3033124927 cites W2071818162 @default.
• W3033124927 cites W2078614449 @default.
• W3033124927 cites W2095826251 @default.
• W3033124927 cites W2113035823 @default.
• W3033124927 cites W2126142987 @default.
• W3033124927 cites W2127616923 @default.
• W3033124927 cites W2130085343 @default.
• W3033124927 cites W2137479474 @default.
• W3033124927 cites W2143830618 @default.
• W3033124927 cites W2148707299 @default.
• W3033124927 cites W2149407048 @default.
• W3033124927 cites W2171104276 @default.
• W3033124927 cites W2179796747 @default.
• W3033124927 cites W2266849806 @default.
• W3033124927 cites W2291531085 @default.
• W3033124927 cites W2315075044 @default.
• W3033124927 cites W2320709876 @default.
• W3033124927 cites W2343945585 @default.
• W3033124927 cites W2352211028 @default.
• W3033124927 cites W2363356008 @default.
• W3033124927 cites W2428630017 @default.
• W3033124927 cites W2469833642 @default.
• W3033124927 cites W2502703983 @default.
• W3033124927 cites W2504398253 @default.
• W3033124927 cites W2546458812 @default.
• W3033124927 cites W2551013093 @default.
• W3033124927 cites W2553388903 @default.
• W3033124927 cites W2559358813 @default.
• W3033124927 cites W2564515303 @default.
• W3033124927 cites W2612116823 @default.
• W3033124927 cites W2613362156 @default.
• W3033124927 cites W2745499313 @default.
• W3033124927 cites W2755733485 @default.
• W3033124927 cites W2765750906 @default.
• W3033124927 cites W2770833600 @default.
• W3033124927 cites W2788624958 @default.
• W3033124927 cites W2801965474 @default.
• W3033124927 cites W2803236549 @default.
• W3033124927 cites W2806103948 @default.
• W3033124927 cites W2808703900 @default.
• W3033124927 cites W2885721840 @default.
• W3033124927 cites W2886851393 @default.
• W3033124927 cites W2886965930 @default.
• W3033124927 cites W2887197296 @default.
• W3033124927 cites W2889271032 @default.
• W3033124927 cites W2897299514 @default.
• W3033124927 cites W2899300405 @default.
• W3033124927 cites W2905231927 @default.
• W3033124927 cites W2921324163 @default.
• W3033124927 cites W2924341172 @default.
• W3033124927 cites W2964746205 @default.
• W3033124927 cites W2974246087 @default.
• W3033124927 cites W2975871857 @default.
• W3033124927 cites W2982372249 @default.
• W3033124927 cites W2990834096 @default.
• W3033124927 cites W3007024906 @default.
• W3033124927 cites W67716143 @default.
• W3033124927 doi "https://doi.org/10.1038/s41379-020-0588-y" @default.
• W3033124927 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32504035" @default.
• W3033124927 hasPublicationYear "2020" @default.
• W3033124927 type Work @default.
• W3033124927 sameAs 3033124927 @default.
• W3033124927 citedByCount "29" @default.
• W3033124927 countsByYear W30331249272021 @default.
• W3033124927 countsByYear W30331249272022 @default.
• W3033124927 countsByYear W30331249272023 @default.

• next