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- W3033131456 abstract "Cathepsin K (CatK) is one of the most potent proteases in lysosomal cysteine proteases family, of which the main function is to mediate bone resorption. Currently, CatK is among the most attractive targets for anti-osteoporosis drug development. Although many pharmaceutical companies are working on the development of selective inhibitors for CatK, there is no FDA approved drug until now. Odanacatib (ODN) developed by Merck & Co. is the only CatK inhibitor candidate that demonstrated high therapeutic efficacy in patients with postmenopausal osteoporosis in Phase III clinical trials. Unexpectedly, due to the undesirable adverse effects in non-bone tissues, i.e. higher incidence of cardiovascular and cerebrovascular events versus the placebo group, the development of ODN was finally stopped. Therefore, it arouses widely interests for researchers to find out whether the activity of CatK has far-reaching effects throughout various organs besides bone tissues. Many studies have proved that CatK not only demonstrates vastly different functional activities beyond bone but also is involving in various diseases beyond the musculoskeletal system. This review summarizes the most essential functional roles of CatK in bone and beyond bone. Besides summarizing, we also highlight the potential off-target side effects of inhibiting CatK in non-bone areas in this review." @default.
- W3033131456 created "2020-06-12" @default.
- W3033131456 creator A5004254942 @default.
- W3033131456 creator A5005303316 @default.
- W3033131456 creator A5008178560 @default.
- W3033131456 creator A5012331150 @default.
- W3033131456 creator A5034650211 @default.
- W3033131456 creator A5041824334 @default.
- W3033131456 creator A5091798361 @default.
- W3033131456 date "2020-06-04" @default.
- W3033131456 modified "2023-10-13" @default.
- W3033131456 title "Cathepsin K: The Action in and Beyond Bone" @default.
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