Matches in SemOpenAlex for { <https://semopenalex.org/work/W3033138611> ?p ?o ?g. }
- W3033138611 abstract "Abstract Cerebral small vessel disease (CSVD) is a widespread condition associated to stroke, dementia and depression. To shed light on its opaque pathophysiology, we conducted a neuroimaging study aiming to assess the location of CSVD-induced damage in the human brain network. Structural connectomes of 930 subjects of the Hamburg City Health Study were reconstructed from diffusion weighted imaging. The connectome edges were partitioned into groups according to specific schemes: (1) connection to grey matter regions, (2) course and length of underlying streamlines. Peak-width of skeletonised mean diffusivity (PSMD) - a surrogate marker for CSVD - was related to each edge group’s connectivity in a linear regression analysis allowing localisation of CSVD-induced effects. PSMD was associated with statistically significant decreases in connectivity of most investigated edge groups except those involved in connecting limbic, insular, temporal or cerebellar regions. Connectivity of interhemispheric and long intrahemispheric edges as well as edges connecting subcortical and frontal brain regions decreased most severely with increasing PSMD. In conclusion, MRI findings of CSVD are associated with widespread impairment of structural brain network connectivity, which supports the understanding of CSVD as a global brain disease. The pattern of regional preference might provide a link to clinical phenotypes of CSVD." @default.
- W3033138611 created "2020-06-12" @default.
- W3033138611 creator A5003684003 @default.
- W3033138611 creator A5013144930 @default.
- W3033138611 creator A5020509478 @default.
- W3033138611 creator A5025865872 @default.
- W3033138611 creator A5034887790 @default.
- W3033138611 creator A5044111355 @default.
- W3033138611 creator A5050816239 @default.
- W3033138611 creator A5054165851 @default.
- W3033138611 creator A5061175108 @default.
- W3033138611 creator A5073470250 @default.
- W3033138611 creator A5073536792 @default.
- W3033138611 creator A5076351525 @default.
- W3033138611 date "2020-06-08" @default.
- W3033138611 modified "2023-10-18" @default.
- W3033138611 title "Network Localisation of White Matter Damage in Cerebral Small Vessel Disease" @default.
- W3033138611 cites W1567767941 @default.
- W3033138611 cites W1965894642 @default.
- W3033138611 cites W1967159562 @default.
- W3033138611 cites W2019105362 @default.
- W3033138611 cites W2019307288 @default.
- W3033138611 cites W2020698869 @default.
- W3033138611 cites W2032756463 @default.
- W3033138611 cites W2043522411 @default.
- W3033138611 cites W2048943469 @default.
- W3033138611 cites W2054180055 @default.
- W3033138611 cites W2072290762 @default.
- W3033138611 cites W2077066095 @default.
- W3033138611 cites W2101135654 @default.
- W3033138611 cites W2104901197 @default.
- W3033138611 cites W2112090702 @default.
- W3033138611 cites W2117415070 @default.
- W3033138611 cites W2120741776 @default.
- W3033138611 cites W2122294423 @default.
- W3033138611 cites W2122477279 @default.
- W3033138611 cites W2126428800 @default.
- W3033138611 cites W2140771515 @default.
- W3033138611 cites W2144958050 @default.
- W3033138611 cites W2146048843 @default.
- W3033138611 cites W2150667092 @default.
- W3033138611 cites W2158742097 @default.
- W3033138611 cites W2165985389 @default.
- W3033138611 cites W2199925433 @default.
- W3033138611 cites W2291469492 @default.
- W3033138611 cites W2471406153 @default.
- W3033138611 cites W2504084072 @default.
- W3033138611 cites W2517883070 @default.
- W3033138611 cites W2561525619 @default.
- W3033138611 cites W2597317078 @default.
- W3033138611 cites W2622948156 @default.
- W3033138611 cites W2766639217 @default.
- W3033138611 cites W2771227124 @default.
- W3033138611 cites W2791577590 @default.
- W3033138611 cites W2797578916 @default.
- W3033138611 cites W2804435536 @default.
- W3033138611 cites W2914816077 @default.
- W3033138611 cites W2915743548 @default.
- W3033138611 cites W2922738555 @default.
- W3033138611 cites W2970898057 @default.
- W3033138611 cites W2977740913 @default.
- W3033138611 cites W2987468537 @default.
- W3033138611 cites W795339718 @default.
- W3033138611 doi "https://doi.org/10.1038/s41598-020-66013-w" @default.
- W3033138611 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7280237" @default.
- W3033138611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32514044" @default.
- W3033138611 hasPublicationYear "2020" @default.
- W3033138611 type Work @default.
- W3033138611 sameAs 3033138611 @default.
- W3033138611 citedByCount "26" @default.
- W3033138611 countsByYear W30331386112020 @default.
- W3033138611 countsByYear W30331386112021 @default.
- W3033138611 countsByYear W30331386112022 @default.
- W3033138611 countsByYear W30331386112023 @default.
- W3033138611 crossrefType "journal-article" @default.
- W3033138611 hasAuthorship W3033138611A5003684003 @default.
- W3033138611 hasAuthorship W3033138611A5013144930 @default.
- W3033138611 hasAuthorship W3033138611A5020509478 @default.
- W3033138611 hasAuthorship W3033138611A5025865872 @default.
- W3033138611 hasAuthorship W3033138611A5034887790 @default.
- W3033138611 hasAuthorship W3033138611A5044111355 @default.
- W3033138611 hasAuthorship W3033138611A5050816239 @default.
- W3033138611 hasAuthorship W3033138611A5054165851 @default.
- W3033138611 hasAuthorship W3033138611A5061175108 @default.
- W3033138611 hasAuthorship W3033138611A5073470250 @default.
- W3033138611 hasAuthorship W3033138611A5073536792 @default.
- W3033138611 hasAuthorship W3033138611A5076351525 @default.
- W3033138611 hasBestOaLocation W30331386111 @default.
- W3033138611 hasConcept C126838900 @default.
- W3033138611 hasConcept C142724271 @default.
- W3033138611 hasConcept C143409427 @default.
- W3033138611 hasConcept C149550507 @default.
- W3033138611 hasConcept C15744967 @default.
- W3033138611 hasConcept C16568411 @default.
- W3033138611 hasConcept C169760540 @default.
- W3033138611 hasConcept C2777670902 @default.
- W3033138611 hasConcept C2778013878 @default.
- W3033138611 hasConcept C2779134260 @default.
- W3033138611 hasConcept C2779483572 @default.
- W3033138611 hasConcept C2781192897 @default.