FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3033139816> ?p ?o ?g. }

• W3033139816 endingPage "537" @default.
• W3033139816 startingPage "528" @default.
• W3033139816 abstract "Context:Chloranthus serratus [(Thunb.) Roem. et Schult, (Chloranthaceae)] is a folk medicine used for the treatment of rheumatoid arthritis.Objective: The aim of this study was to investigate anti-arthritic effects of the ethanol extracts of the roots (ER), stems (ES) and leaves (EL) of C. serratus on adjuvant arthritis rats and related mechanisms.Materials and methods: The rats were immunized by intradermal injection of complete Freund's adjuvant (CFA, 0.18 mL) into the right hind feet, and received intragastric administrations of the ER, ES and EL (2.07, 1.61 and 0.58 g/kg/d, respectively) for 14 days. The anti-arthritic activity was assessed by swelling rates, serum indicators, antioxidant capacity, histopathological and immunohistochemical analyses.Results: The LD50 of the ER, ES and EL was higher than 10.35, 8.05 and 2.90 g/kg/p.o., respectively. Extract treatments decreased swelling rates, tumour necrosis factor-alpha (TNF-α), vascular endothelial growth factor (VEGF), interleukin 1 beta (IL-1β), migration inhibitory factor 1 (MIF-1), immunoglobulin G (IgG) and immunoglobulin M (IgM) levels and positive expression of VEGF in the arthritic rats (p < 0.01 or p < 0.05). The ER significantly decreased NO (3.91 ± 0.61 µmol/L), IL-6 (75.67 ± 16.83 pg/mL) and malondialdehyde (MDA) (2.28 ± 0.32 nmol/mL) contents and clearly increased IFN-γ (2082 ± 220.93 pg/mL) and superoxide dismutase (SOD) (601.98 ± 38.40 U/mL) levels. The ES and EL did not reverse the changes in some indicators. All the extracts alleviated inflammatory cell infiltration and synovial cell proliferation. Among them, the ER was the most pronounced.Discussion and conclusions: ER exerts the most promising effects, as shown by inhibiting the releases of inflammatory cytokines and enhancing antioxidant capacity, which provides a scientific basis for further research on C. serratus and its clinical applications." @default.
• W3033139816 created "2020-06-12" @default.
• W3033139816 creator A5000113633 @default.
• W3033139816 creator A5027531484 @default.
• W3033139816 creator A5031563836 @default.
• W3033139816 creator A5062967630 @default.
• W3033139816 creator A5069101595 @default.
• W3033139816 creator A5081085876 @default.
• W3033139816 creator A5089851404 @default.
• W3033139816 date "2020-01-01" @default.
• W3033139816 modified "2023-09-27" @default.
• W3033139816 title "Anti-inflammatory effects of the root, stem and leaf extracts of <i>Chloranthus serratus</i> on adjuvant-induced arthritis in rats" @default.
• W3033139816 cites W1524512903 @default.
• W3033139816 cites W1972110277 @default.
• W3033139816 cites W1994972665 @default.
• W3033139816 cites W2009390670 @default.
• W3033139816 cites W2021731768 @default.
• W3033139816 cites W2041774799 @default.
• W3033139816 cites W2068097628 @default.
• W3033139816 cites W2080712292 @default.
• W3033139816 cites W2109967949 @default.
• W3033139816 cites W2118447282 @default.
• W3033139816 cites W2156374015 @default.
• W3033139816 cites W2237594791 @default.
• W3033139816 cites W2310289511 @default.
• W3033139816 cites W2397788451 @default.
• W3033139816 cites W2400223198 @default.
• W3033139816 cites W2411066679 @default.
• W3033139816 cites W2556701090 @default.
• W3033139816 cites W2587812161 @default.
• W3033139816 cites W2671609735 @default.
• W3033139816 cites W2745813958 @default.
• W3033139816 cites W2791375114 @default.
• W3033139816 cites W2801071713 @default.
• W3033139816 cites W2802775266 @default.
• W3033139816 cites W2848013087 @default.
• W3033139816 cites W2911434020 @default.
• W3033139816 cites W2914013605 @default.
• W3033139816 cites W2921812500 @default.
• W3033139816 cites W2943575556 @default.
• W3033139816 cites W2994221010 @default.
• W3033139816 doi "https://doi.org/10.1080/13880209.2020.1767159" @default.
• W3033139816 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32503379" @default.
• W3033139816 hasPublicationYear "2020" @default.
• W3033139816 type Work @default.
• W3033139816 sameAs 3033139816 @default.
• W3033139816 citedByCount "10" @default.
• W3033139816 countsByYear W30331398162020 @default.
• W3033139816 countsByYear W30331398162021 @default.
• W3033139816 countsByYear W30331398162022 @default.
• W3033139816 countsByYear W30331398162023 @default.
• W3033139816 crossrefType "journal-article" @default.
• W3033139816 hasAuthorship W3033139816A5000113633 @default.
• W3033139816 hasAuthorship W3033139816A5027531484 @default.
• W3033139816 hasAuthorship W3033139816A5031563836 @default.
• W3033139816 hasAuthorship W3033139816A5062967630 @default.
• W3033139816 hasAuthorship W3033139816A5069101595 @default.
• W3033139816 hasAuthorship W3033139816A5081085876 @default.
• W3033139816 hasAuthorship W3033139816A5089851404 @default.
• W3033139816 hasBestOaLocation W30331398161 @default.
• W3033139816 hasConcept C126322002 @default.
• W3033139816 hasConcept C167734588 @default.
• W3033139816 hasConcept C185592680 @default.
• W3033139816 hasConcept C203014093 @default.
• W3033139816 hasConcept C2775838275 @default.
• W3033139816 hasConcept C2776151105 @default.
• W3033139816 hasConcept C2777025900 @default.
• W3033139816 hasConcept C2777077863 @default.
• W3033139816 hasConcept C2778401633 @default.
• W3033139816 hasConcept C556039675 @default.
• W3033139816 hasConcept C71924100 @default.
• W3033139816 hasConcept C98274493 @default.
• W3033139816 hasConceptScore W3033139816C126322002 @default.
• W3033139816 hasConceptScore W3033139816C167734588 @default.
• W3033139816 hasConceptScore W3033139816C185592680 @default.
• W3033139816 hasConceptScore W3033139816C203014093 @default.
• W3033139816 hasConceptScore W3033139816C2775838275 @default.
• W3033139816 hasConceptScore W3033139816C2776151105 @default.
• W3033139816 hasConceptScore W3033139816C2777025900 @default.
• W3033139816 hasConceptScore W3033139816C2777077863 @default.
• W3033139816 hasConceptScore W3033139816C2778401633 @default.
• W3033139816 hasConceptScore W3033139816C556039675 @default.
• W3033139816 hasConceptScore W3033139816C71924100 @default.
• W3033139816 hasConceptScore W3033139816C98274493 @default.
• W3033139816 hasIssue "1" @default.
• W3033139816 hasLocation W30331398161 @default.
• W3033139816 hasLocation W30331398162 @default.
• W3033139816 hasLocation W30331398163 @default.
• W3033139816 hasOpenAccess W3033139816 @default.
• W3033139816 hasPrimaryLocation W30331398161 @default.
• W3033139816 hasRelatedWork W1963764635 @default.
• W3033139816 hasRelatedWork W2049863417 @default.
• W3033139816 hasRelatedWork W2154735061 @default.
• W3033139816 hasRelatedWork W2366394575 @default.
• W3033139816 hasRelatedWork W2387681069 @default.
• W3033139816 hasRelatedWork W2748952813 @default.
• W3033139816 hasRelatedWork W2899084033 @default.
• W3033139816 hasRelatedWork W2945407096 @default.

• next