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- W3033140116 abstract "Staphylococcus aureus fatty acid kinase FakA is necessary for the incorporation of exogenous fatty acids into the lipid membrane. We previously demonstrated that the inactivation of fakA leads to decreased α-hemolysin (Hla) production but increased expression of the proteases SspAB and aureolysin in vitro , and that the Δ fakA mutant causes larger lesions than the wild type (WT) during murine skin infection. As expected, necrosis is Hla dependent in the presence or absence of FakA, as both hla and hla Δ fakA mutants are unable to cause necrosis of the skin." @default.
- W3033140116 created "2020-06-12" @default.
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- W3033140116 date "2020-07-21" @default.
- W3033140116 modified "2023-09-23" @default.
- W3033140116 title "Staphylococcus aureus Fatty Acid Kinase FakA Modulates Pathogenesis during Skin Infection via Proteases" @default.
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- W3033140116 doi "https://doi.org/10.1128/iai.00163-20" @default.
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