Matches in SemOpenAlex for { <https://semopenalex.org/work/W3033142040> ?p ?o ?g. }
- W3033142040 endingPage "618" @default.
- W3033142040 startingPage "611" @default.
- W3033142040 abstract "Abstract Background and Objective Recent COVID‐19 pandemic guidelines recommend genomic assessment of core biopsies to help guide treatment decisions in estrogen receptor (ER)‐positive early‐stage breast cancer. Herein we characterize biopsy and excisional breast cancer specimens submitted for 21‐gene testing. Methods US samples submitted to Genomic Health for 21‐gene testing (01/2004‐04/2020) were assessed by pathologists and analyzed by a standardized quantitative reverse transcription‐polymerase chain reaction. Predefined cutoffs were: ESR1 (positive ≥6.5), PGR (positive ≥5.5), and ERBB2 (negative <10.7). ER status by immunohistochemistry (IHC) and lymph node status were determined locally. Median and interquartile range were reported for continuous variables, and total and percent for categorical variables. Distributions were assessed overall, by age, and by nodal involvement. Results Of 919 701 samples analyzed, 13% were biopsies and 87% were excisions. Initial assay success rates were 94.5% (biopsies) and 97.3% (excisions). ER IHC concordance with central ESR1 was 96.8% (biopsies) and 97.6% (excisions). Biopsy and excisional medians were: Recurrence Score results 16 (each); ESR1 10.2 (each); PGR 7.7 and 7.6; ERBB2 9.4 and 9.2, respectively. Conclusions Biopsy submissions for 21‐gene testing are common and consistently generate results that are very similar to the experience with excisions. The 21‐gene test can be performed reliably on core biopsies." @default.
- W3033142040 created "2020-06-12" @default.
- W3033142040 creator A5002510470 @default.
- W3033142040 creator A5005556055 @default.
- W3033142040 creator A5016401075 @default.
- W3033142040 creator A5028445048 @default.
- W3033142040 creator A5041284541 @default.
- W3033142040 creator A5055444139 @default.
- W3033142040 creator A5059088739 @default.
- W3033142040 creator A5078606543 @default.
- W3033142040 creator A5084313309 @default.
- W3033142040 creator A5086658498 @default.
- W3033142040 date "2020-06-04" @default.
- W3033142040 modified "2023-10-06" @default.
- W3033142040 title "Molecular characterization of breast cancer needle core biopsy specimens by the 21‐gene Breast Recurrence Score test" @default.
- W3033142040 cites W1923080481 @default.
- W3033142040 cites W1990360965 @default.
- W3033142040 cites W1995871893 @default.
- W3033142040 cites W2012614658 @default.
- W3033142040 cites W2015960413 @default.
- W3033142040 cites W2021702652 @default.
- W3033142040 cites W2040204941 @default.
- W3033142040 cites W2049820079 @default.
- W3033142040 cites W2070775961 @default.
- W3033142040 cites W2079622077 @default.
- W3033142040 cites W2083268461 @default.
- W3033142040 cites W2093986016 @default.
- W3033142040 cites W2096997068 @default.
- W3033142040 cites W2105882193 @default.
- W3033142040 cites W2109462843 @default.
- W3033142040 cites W2113344831 @default.
- W3033142040 cites W2125396123 @default.
- W3033142040 cites W2129859749 @default.
- W3033142040 cites W2130639106 @default.
- W3033142040 cites W2135170635 @default.
- W3033142040 cites W2148952969 @default.
- W3033142040 cites W2160377567 @default.
- W3033142040 cites W2170687251 @default.
- W3033142040 cites W2190954851 @default.
- W3033142040 cites W2331581953 @default.
- W3033142040 cites W2410853227 @default.
- W3033142040 cites W2467606258 @default.
- W3033142040 cites W2498058066 @default.
- W3033142040 cites W2523941353 @default.
- W3033142040 cites W2592904882 @default.
- W3033142040 cites W2598843906 @default.
- W3033142040 cites W2605509116 @default.
- W3033142040 cites W2759663528 @default.
- W3033142040 cites W2805734855 @default.
- W3033142040 cites W2806209829 @default.
- W3033142040 cites W2891728587 @default.
- W3033142040 cites W2899814155 @default.
- W3033142040 cites W2903832937 @default.
- W3033142040 cites W2977150399 @default.
- W3033142040 cites W2999400187 @default.
- W3033142040 cites W3012268121 @default.
- W3033142040 cites W3018098307 @default.
- W3033142040 cites W3033142040 @default.
- W3033142040 cites W49108541 @default.
- W3033142040 doi "https://doi.org/10.1002/jso.26050" @default.
- W3033142040 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7496790" @default.
- W3033142040 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32497318" @default.
- W3033142040 hasPublicationYear "2020" @default.
- W3033142040 type Work @default.
- W3033142040 sameAs 3033142040 @default.
- W3033142040 citedByCount "14" @default.
- W3033142040 countsByYear W30331420402020 @default.
- W3033142040 countsByYear W30331420402021 @default.
- W3033142040 countsByYear W30331420402022 @default.
- W3033142040 countsByYear W30331420402023 @default.
- W3033142040 crossrefType "journal-article" @default.
- W3033142040 hasAuthorship W3033142040A5002510470 @default.
- W3033142040 hasAuthorship W3033142040A5005556055 @default.
- W3033142040 hasAuthorship W3033142040A5016401075 @default.
- W3033142040 hasAuthorship W3033142040A5028445048 @default.
- W3033142040 hasAuthorship W3033142040A5041284541 @default.
- W3033142040 hasAuthorship W3033142040A5055444139 @default.
- W3033142040 hasAuthorship W3033142040A5059088739 @default.
- W3033142040 hasAuthorship W3033142040A5078606543 @default.
- W3033142040 hasAuthorship W3033142040A5084313309 @default.
- W3033142040 hasAuthorship W3033142040A5086658498 @default.
- W3033142040 hasBestOaLocation W30331420401 @default.
- W3033142040 hasConcept C119060515 @default.
- W3033142040 hasConcept C121608353 @default.
- W3033142040 hasConcept C126322002 @default.
- W3033142040 hasConcept C142724271 @default.
- W3033142040 hasConcept C143998085 @default.
- W3033142040 hasConcept C160798450 @default.
- W3033142040 hasConcept C2775934546 @default.
- W3033142040 hasConcept C2780849966 @default.
- W3033142040 hasConcept C530470458 @default.
- W3033142040 hasConcept C71924100 @default.
- W3033142040 hasConceptScore W3033142040C119060515 @default.
- W3033142040 hasConceptScore W3033142040C121608353 @default.
- W3033142040 hasConceptScore W3033142040C126322002 @default.
- W3033142040 hasConceptScore W3033142040C142724271 @default.
- W3033142040 hasConceptScore W3033142040C143998085 @default.
- W3033142040 hasConceptScore W3033142040C160798450 @default.